The role of mechanical loading in the onset and progression of osteoarthritis

被引：357

作者：

Griffin, TM

Guilak, F

机构：

[1] Duke Univ, Med Ctr, Orthopaed Res Labs, Dept Surg, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Dept Biomed Engn, Durham, NC 27710 USA

来源：

EXERCISE AND SPORT SCIENCES REVIEWS | 2005年 / 33卷 / 04期

关键词：

arthritis; obesity; metabolic syndrome X; chondrocyte; exercise; biomechanics; adipokine;

D O I：

10.1097/00003677-200510000-00008

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Osteoarthritis is a progressive joint disease characterized by an imbalance of articular cartilage biosynthesis and degradation attributed to both inflammatory and biomechanical factors. Whereas moderate mechanical loading appears necessary for maintaining healthy cartilage, abnormal joint loading increases the risk of osteoarthritis. Obesity-induced osteoarthritis and the benefits of physical activity may be mediated by systemic levels of proinflammatory mediators as well as local biomechanical factors in the joint.

引用

页码：195 / 200

页数：6

共 15 条

[1] Normal and pathological adaptations of articular cartilage to joint loading [J].