Hypertension drives parenchymal β-amyloid accumulation in the brain parenchyma

被引：34

作者：

Bueche, Celine Z. ^{[1
,2
]}

Hawkes, Cheryl ^{[3
]}

Garz, Cornelia ^{[1
]}

Vielhaber, Stefan ^{[1
,2
]}

Attems, Johannes ^{[4
]}

Knight, Robert T. ^{[5
,6
]}

Reymann, Klaus ^{[2
]}

Heinze, Hans-Jochen ^{[1
,2
]}

Carare, Roxana O. ^{[3
]}

Schreiber, Stefanie ^{[1
,2
]}

机构：

[1] Otto von Guericke Univ, Dept Neurol, Leipziger Str 44, D-39120 Magdeburg, Germany

[2] German Ctr Neurodegenerat Dis DZNE, Magdeburg, Germany

[3] Univ Southampton, Fac Med, Southampton, Hants, England

[4] Newcastle Univ, Inst Hlth & Aging, Newcastle, NSW, Australia

[5] Univ Calif Berkeley, Helen Wills Neuroscience Inst, Berkeley, CA 94720 USA

[6] Univ Calif Berkeley, Dept Psychol, 3210 Tolman Hall, Berkeley, CA 94720 USA

来源：

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY | 2014年 / 1卷 / 02期

基金：

英国医学研究理事会;

关键词：

ALZHEIMERS-DISEASE; DEMENTIA; MECHANISMS; MODELS;

D O I：

10.1002/acn3.27

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

There is substantial controversy regarding the causative role of amyloid beta (A beta) deposition in Alzheimer's disease (AD). The cerebrovasculature plays an important role in the elimination of A beta from the brain and hypertension is a well-known risk factor for AD. In spontaneously hypertensive stroke-prone rats (SHRSP), an animal model of chronic arterial hypertension, cerebral small vessel disease (CSVD) leads to age-dependent parenchymal A beta accumulation similar to that observed in AD. These data approve the neuropathological link between CSVD and AD, confirm the challenge that parenchymal A beta deposition is a specific marker for AD and disclose the meaning of SHRSP as valid experimental model to investigate the association between hypertension, CSVD, and A beta plaques.

引用

页码：124 / 129

页数：6

共 20 条

[1]

The Animal Models of Dementia and Alzheimer's Disease for Pre-Clinical Testing and Clinical Translation [J].

Anand, Akshay ;

Banik, Avijit ;

Thakur, Keshav ;

Masters, Colin L. .

CURRENT ALZHEIMER RESEARCH, 2012, 9 (09) :1010-1029

[2]

Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease [J].

Bell, Robert D. ;

Zlokovic, Berislav V. .

ACTA NEUROPATHOLOGICA, 2009, 118 (01) :103-113

[3]

Microbleeds in cerebral small vessel disease [J].

Braun, Holger ;

Schreiber, Stefanie .

LANCET NEUROLOGY, 2013, 12 (08) :735-736

[4]

Review: Cerebral amyloid angiopathy, prion angiopathy, CADASIL and the spectrum of protein elimination failure angiopathies (PEFA) in neurodegenerative disease with a focus on therapy [J].

Carare, R. O. ;

Hawkes, C. A. ;

Jeffrey, M. ;

Kalaria, R. N. ;

Weller, R. O. .

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 2013, 39 (06) :593-611

[5]

The role of amyloid β in the pathogenesis of Alzheimer's disease [J].

Gilbert, Barnabas James .

JOURNAL OF CLINICAL PATHOLOGY, 2013, 66 (05) :362-366

[6]

Triple fluorescence labelling of neuronal, glial and vascular markers revealing pathological alterations in various animal models [J].

Haertig, Wolfgang ;

Reichenbach, Andreas ;

Voigt, Cornelia ;

Boltze, Johannes ;

Bulavina, Larysa ;

Schuhmann, Martin U. ;

Seeger, Johannes ;

Schusser, Gerald F. ;

Freytag, Christiane ;

Grosche, Jens .

JOURNAL OF CHEMICAL NEUROANATOMY, 2009, 37 (02) :128-138

[7]

Morphological and Pathological Evolution of the Brain Microcirculation in Aging and Alzheimer's Disease [J].

Hunter, Jesse M. ;

Kwan, Jason ;

Malek-Ahmadi, Michael ;

Maarouf, Chera L. ;

Kokjohn, Tyler A. ;

Belden, Christine ;

Sabbagh, Marwan N. ;

Beach, Thomas G. ;

Roher, Alex E. .

PLOS ONE, 2012, 7 (05)

[8]

Experimental models of vascular dementia and vascular cognitive impairment: a systematic review [J].

Jiwa, Nadim S. ;

Garrard, Peter ;

Hainsworth, Atticus H. .

JOURNAL OF NEUROCHEMISTRY, 2010, 115 (04) :814-828

[9]

Small vessel disease and Alzheimer's dementia: Pathological considerations [J].

Kalaria, RN .

CEREBROVASCULAR DISEASES, 2002, 13 :48-52

[10]

Animal Models of Alzheimer Disease [J].

LaFerla, Frank M. ;

Green, Kim N. .

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2012, 2 (11)

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