Chiral N-heterocyclic carbene ligands for asymmetric catalytic oxindole synthesis

被引：198

作者：

Jia, Yi-Xia ^{[1
]}

Hillgren, J. Mikael ^{[2
]}

Watson, Emma L. ^{[2
]}

Marsden, Stephen P. ^{[2
]}

Kuendig, E. Peter ^{[1
]}

机构：

[1] Univ Geneva, Dept Organ Chem, CH-1211 Geneva 4, Switzerland

[2] Univ Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England

来源：

CHEMICAL COMMUNICATIONS | 2008年 / 34期

基金：

英国工程与自然科学研究理事会; 瑞士国家科学基金会;

关键词：

D O I：

10.1039/b810858g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The Pd-catalysed asymmetric intramolecular alpha-arylation of amide enolates containing heteroatom substituents gives chiral 3-alkoxy or 3-aminooxindoles in high yield and with enantioselectivities up to 97% ee when a new chiral N-heterocyclic carbene ligand is used.

引用

页码：4040 / 4042

页数：3

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