Social dominance in monkeys:: dopamine D2 receptors and cocaine self-administration

被引:450
作者
Morgan, D
Grant, KA
Gage, HD
Mach, RH
Kaplan, JR
Prioleau, O
Nader, SH
Buchheimer, N
Ehrenkaufer, RL
Nader, MA
机构
[1] Wake Forest Univ, Bowman Gray Sch Med, Dept Physiol & Pharmacol, Winston Salem, NC 27157 USA
[2] Wake Forest Univ, Bowman Gray Sch Med, Dept Radiol, Winston Salem, NC 27157 USA
[3] Wake Forest Univ, Bowman Gray Sch Med, Dept Pathol Comparat Med, Winston Salem, NC 27157 USA
[4] Wake Forest Univ, Bowman Gray Sch Med, Dept Anthropol, Winston Salem, NC 27157 USA
关键词
D O I
10.1038/nn798
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Disruption of the dopaminergic system has been implicated in the etiology of many pathological conditions, including drug addiction. Here we used positron emission tomography (PET) imaging to study brain dopaminergic function in individually housed and in socially housed cynomolgus macaques (n = 20). Whereas the monkeys did not differ during individual housing, social housing increased the amount or availability of dopamine D-2 receptors in dominant monkeys and produced no change in subordinate monkeys. These neurobiological changes had an important behavioral influence as demonstrated by the finding that cocaine functioned as a reinforcer in subordinate but not dominant monkeys. These data demonstrate that alterations in an organism's environment can produce profound biological changes that have important behavioral associations, including vulnerability to cocaine addiction.
引用
收藏
页码:169 / 174
页数:6
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