Potent immunosuppressive C32-O-arylethyl ether derivatives of ascomycin with reduced toxicity.

被引：4

作者：

Armstrong, HM

Wong, F

Holmes, MA

Sinclair, PJ

Goulet, MT

Dumont, FJ

Staruch, M

Koprak, S

Peterson, LB

Rosa, R

Wilusz, MB

Wiederrecht, GJ

Cryan, JG

Wyvratt, MJ

Parsons, WH

机构：

[1] Merck Res Labs, Dept Med Chem, Rahway, NJ 07065 USA

[2] Merck Res Labs, Dept Immunol Res, Rahway, NJ 07065 USA

[3] Merck Res Labs, Dept Mol Pharmacol, Rahway, NJ 07065 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 14期

关键词：

D O I：

10.1016/S0960-894X(99)00336-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of C32-O-arylethyl ether derivatives of ascomycin that possess equivalent immunosuppressant activity but reduced toxicity, compared to FK-506, is described. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2089 / 2094

页数：6

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