Lipid rafts and little caves - Compartmentalized signalling in membrane microdomains

被引：200

作者：

Zajchowski, LD

Robbins, SM

机构：

[1] Univ Calgary, Dept Oncol, Calgary, AB T2N 4N1, Canada

[2] Univ Calgary, Dept Biochem & Mol Biol, Calgary, AB T2N 4N1, Canada

来源：

EUROPEAN JOURNAL OF BIOCHEMISTRY | 2002年 / 269卷 / 03期

关键词：

lipid rafts; caveolae; caveolin; membrane microdomains; signal transduction; glycosylphosphatidylinositol anchor; cholesterol; glycosphingolipids;

D O I：

10.1046/j.0014-2956.2001.02715.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lipid rafts are liquid-ordered membrane microdomains with a unique protein and lipid composition found on the plasma membrane of most, if not all, mammalian cells. A large number of signalling molecules are concentrated within rafts, which have been proposed to function as signalling centres capable of facilitating efficient and specific signal transduction. This review summarizes current knowledge regarding the composition. structure, and dynamic nature of lipid rafts. as well as a number of different signalling pathways that are compartmentalized within these microdomains. Potential mechanisms through which lipid rafts carry out their specialized role in signalling are discussed in light of recent experimental evidence.

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收藏

页码：737 / 752

页数：16

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