New synthesis of cis-3,4-diaryl-1-tosylpyrrolidines

被引：15

作者：

Chang, Meng-Yang ^{[1
]}

Pai, Chun-Li

Lin, Chun-Yu

机构：

[1] Natl Univ Kaohsiung, Dept Appl Chem, Kaohsiung 811, Taiwan

[2] Natl Sun Yat Sen Univ, Dept Chem, Kaohsiung 804, Taiwan

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 22期

关键词：

4-aryl-1,2,5,6-tetrahydropyridines; 3-arylpyrrolines; cis-3,4-diarylpyrrolidines; Grignard addition; m-chloroperoxybenzoic acid; boron trifluoride etherate;

D O I：

10.1016/j.tetlet.2006.03.141

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Unsymmetrically substituted cis-3,4-diarylpyrrolidines are synthesized in nearly 25% overall yields starting from 4-aryl-1,2,5,6-tetrahydropyridines by iterative reactions using the combination of m-chloroperoxybenzoic acid (MCPBA) and boron trifluoride etherate (BF3 center dot OEt2) followed by Grignard addition, elimination and hydrogenation sequence. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：3641 / 3644

页数：4

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