IMPROVEMENT IN MEASURES OF DEPRESSED MOOD AND ANHEDONIA, AND FATIGUE, IN A RANDOMIZED, PLACEBO-CONTROLLED, PHASE 2 STUDY OF SIRUKUMAB, A HUMAN ANTI-INTERLEUKIN-6 ANTIBODY, IN PATIENTS WITH RHEUMATOID ARTHRITIS

被引：13

作者：

Hsu, B. ^{[1
]}

Wang, D. ^{[1
]}

Sun, Y. ^{[2
]}

Salvadore, G. ^{[3
]}

Singh, J. ^{[1
]}

Curran, M. ^{[4
]}

Caers, I. ^{[1
]}

Drevets, W. ^{[2
]}

Wittenberg, G. ^{[2
]}

Chen, G. ^{[1
]}

机构：

[1] Janssen R&D LLC, La Jolla, CA USA

[2] Janssen R&D LLC, Raritan, NJ USA

[3] Janssen R&D LLC, Titusville, NJ USA

[4] Janssen R&D LLC, Spring House, PA USA

来源：

ANNALS OF THE RHEUMATIC DISEASES | 2015年 / 74卷

关键词：

D O I：

10.1136/annrheumdis-2015-eular.4081

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

SAT0182

引用

页码：720 / 721

页数：2

共 2 条

[1] Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress [J].

Hodes, Georgia E. ;

Pfau, Madeline L. ;

Leboeuf, Marylene ;

Golden, Sam A. ;

Christoffel, Daniel J. ;

Bregman, Dana ;

Rebusi, Nicole ;

Heshmati, Mitra ;

Aleyasin, Hossein ;

Warren, Brandon L. ;

Lebonte, Benoit ;

Horn, Sarah ;

Lapidus, Kyle A. ;

Stelzhammer, Viktoria ;

Wong, Erik H. F. ;

Bahn, Sabine ;

Krishnan, Vaishnav ;

Bolanos-Guzman, Carlos A. ;

Murrough, James W. ;

Merad, Miriam ;

Russo, Scott J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (45) :16136-16141

[2] Sirukumab, a human anti-interleukin-6 monoclonal antibody: a randomised, 2-part (proof-of-concept and dose-finding), phase II study in patients with active rheumatoid arthritis despite methotrexate therapy [J].

Smolen, Josef S. ;

Weinblatt, Michael E. ;

Sheng, Shihong ;

Zhuang, Yanli ;

Hsu, Benjamin .

ANNALS OF THE RHEUMATIC DISEASES, 2014, 73 (09) :1616-1625

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