Oral cadmium exposure throughout puberty does not inhibit secretion of prolactin, GH and ACTH through dopamine metabolism changes in male rat

被引：7

作者：

Lafuente, A

González-Carracedo, A

Márquez, N

Pazo, D

Esquifino, AI

机构：

[1] Univ Vigo, Fac Ciencias, Toxicol Lab, Orense 32004, Spain

[2] Univ Complutense, Fac Med, Dept Bioquim & Biol Mol 3, E-28040 Madrid, Spain

来源：

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY | 2002年 / 16卷 / 04期

关键词：

cadmium; oral exposure; puberty; dopamine; pituitary hormones;

D O I：

10.1016/S0946-672X(02)80053-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This work analyzed possible dopamine-mediated cadmium effects on plasma protactin, GH and ACTH levels and if these changes were related to metal accumulation. Male rats were treated from day 30 to 60 of life with 50 mg/L of CdCl2 in the drinking water. Cadmium exposure decreased the dopamine (DA) metabolism (DOPAC/DA ratio) in all brain areas studied, and plasma levels of proLactin, GH and ACTH were diminished. The cadmium concentration did not increase nor in hypothalamus nor in the pituitary after the metal exposure. These results suggest that cadmium inhibits the secretion of these pituitary hormones and this inhibitory effect is not mediated by dopamine or the degree of metal accumulation.

引用

页码：249 / 254

页数：6

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