Inhibition of matrix metalloproteinase-1 by dichloromethylene bisphosphonate (Clodronate)

被引：65

作者：

Teronen, O

Konttinen, YT

Lindqvist, C

Salo, T

Ingman, T

Lauhio, A

Ding, Y

Santavirta, S

Valleala, H

Sorsa, T

机构：

[1] UNIV HELSINKI,DEPT PERIODONTOL,FIN-00014 HELSINKI,FINLAND

[2] UNIV HELSINKI,DEPT PEDODONT & ORTHODONT,FIN-00014 HELSINKI,FINLAND

[3] UNIV HELSINKI,DEPT MED,FIN-00014 HELSINKI,FINLAND

[4] UNIV HELSINKI,DEPT ORTHOPED & TRAUMATOL,FIN-00014 HELSINKI,FINLAND

[5] UNIV HELSINKI,DEPT ANAT,FIN-00014 HELSINKI,FINLAND

[6] UNIV HELSINKI,DEPT MED CHEM,FIN-00014 HELSINKI,FINLAND

[7] UNIV OULU,DEPT ORAL & MAXILLOFACIAL SURG & PATHOL,SF-90220 OULU,FINLAND

[8] ORTON INVALID FDN,RES UNIT,HELSINKI,FINLAND

[9] UNIV HELSINKI,DEPT SURG,DEPT ORAL & MAXILLOFACIAL SURG,FIN-00014 HELSINKI,FINLAND

来源：

CALCIFIED TISSUE INTERNATIONAL | 1997年 / 61卷 / 01期

关键词：

collagenase; inhibition; clodronate/biophosphonate; bone destruction;

D O I：

10.1007/s002239900295

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Interstitial collagenase present in human jaw cyst extract and purified human fibroblast-type collagenase (MMP-1) were both efficiently inhibited in vitro by clodronate, an osteoactive, antiresorptive bisphosphonate, The IC50 of clodronate to inhibit MMP-1 is 150 mu M. These findings suggest an extended and hitherto undescribed properties for clodronate/biphosphonates in prevention and treatment of tissue degradation in both bone and soft tissue destructive diseases.

引用

页码：59 / 61

页数：3

共 20 条

[1] Management of myeloma with bisphosphonates [J].