Genetic evidence for the involvement of tau in progressive supranuclear palsy

被引：364

作者：

Conrad, C

Andreadis, A

Trojanowski, JQ

Dickson, DW

Kang, D

Chen, XH

Wiederholt, W

Hansen, L

Masliah, E

Thal, LJ

Katzman, R

Xia, Y

Saitoh, T

机构：

[1] UNIV CALIF SAN DIEGO,SCH MED,DEPT NEUROSCI,LA JOLLA,CA 92093

[2] EUNICE KENNEDY SHRIVER CTR MENTAL RETARDAT INC,DEPT BIOMED SCI,WALTHAM,MA 02154

[3] UNIV PENN,MED CTR,DEPT PATHOL,PHILADELPHIA,PA 19104

[4] ALBERT EINSTEIN COLL MED,DEPT PATHOL,BRONX,NY 10467

来源：

ANNALS OF NEUROLOGY | 1997年 / 41卷 / 02期

关键词：

D O I：

10.1002/ana.410410222

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A dinucleotide repeat polymorphism in a tau intron was identified and used in a case-control study to analyze the genetic association of tau with several neurodegenerative diseases with tau pathology. Subjects with the homozygous tau A0 alleles were excessively represented in the progressive supranuclear palsy (PSP) group, compared with the age-matched healthy control group. Consequently, this allele is more frequently found in PSP than in a group of healthy subjects. This trend was not found in Alzheimer's disease or parkinsonism-dementia complex of Guam, both of which are accompanied by major tau pathology. The result suggests a possible involvement of tau in the pathogenesis of PSP.

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页码：277 / 281

页数：5

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