PPARδ functions as a prostacyclin receptor in blastocyst implantation

被引：87

作者：

Lim, H

Dey, SK

机构：

[1] Brigham & Womens Hosp, Div Genet, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Boston, MA 02115 USA

[3] Univ Kansas, Med Ctr, Ralph L Smith Res Ctr, Dept Mol & Integrat Physiol, Kansas City, KS 66160 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2000年 / 11卷 / 04期

关键词：

D O I：

10.1016/S1043-2760(00)00243-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Peroxisome proliferator-activated receptors (PPARs), members of the nuclear hormone superfamily, are the target of extensive investigation because of their role in various pathophysiological processes. Recently, a novel biological function of PPAR delta, a less studied member of the family, was observed in the mouse. Evidence suggests that cyclooxygenase 2-derived prostacyclin mediates blastocyst implantation via this receptor. In this review, this new function of PPAR delta in implantation is highlighted, and future directions to investigate its mechanism of action are discussed.

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页码：137 / 142

页数：6

相关论文

共 47 条

[1] PPARγ is required for placental, cardiac, and adipose tissue development [J].

Barak, Y ;

Nelson, MC ;

Ong, ES ;

Jones, YZ ;

Ruiz-Lozano, P ;

Chien, KR ;

Koder, A ;

Evans, RM .

MOLECULAR CELL, 1999, 4 (04) :585-595

[2] Novel peroxisome proliferator-activated receptor (PPAR) γ and PPARδ ligands produce distinct biological effects [J].

Berger, J ;

Leibowitz, MD ;

Doebber, TW ;

Elbrecht, A ;

Zhang, B ;

Zhou, GC ;

Biswas, C ;

Cullinan, CA ;

Hayes, NS ;

Li, Y ;

Tanen, M ;

Ventre, J ;

Wu, MS ;

Berger, GD ;

Mosley, R ;

Marquis, R ;

Santini, C ;

Sahoo, SP ;

Tolman, RL ;

Smith, RG ;

Moller, DE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (10) :6718-6725

[3] Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phospholipase A(2) [J].

Bonventre, JV ;

Huang, ZH ;

Taheri, MR ;

OLeary, E ;

Li, E ;

Moskowitz, MA ;

Sapirstein, A .

NATURE, 1997, 390 (6660) :622-625

[4] Differential expression of peroxisome proliferator-activated receptor-α, -β, and -γ during rat embryonic development [J].

Braissant, O ;

Wahli, W .

ENDOCRINOLOGY, 1998, 139 (06) :2748-2754

[5] Arachidonic acid is preferentially metabolized by cyclooxygenase-2 to prostacyclin and prostaglandin E2 [J].

Brock, TG ;

McNish, RW ;

Peters-Golden, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (17) :11660-11666

[6] Developmental expression of the cyclo-oxygenase-1 and cyclo-oxygenase-2 genes in the peri-implantation mouse uterus and their differential regulation by the blastocyst and ovarian steroids [J].

Chakraborty, I ;

Das, SK ;

Wang, J ;

Dey, SK .

JOURNAL OF MOLECULAR ENDOCRINOLOGY, 1996, 16 (02) :107-122

[7]

CHOONJANS KJ, 1996, BIOCHIM BIOPHYS ACTA, V1302, P93

[8] Expression of betacellulin and epiregulin genes in the mouse uterus temporally by the blastocyst solely at the site of its apposition is coincident with the ''window'' of implantation [J].

Das, SK ;

Das, N ;

Wang, J ;

Lim, H ;

Schryver, B ;

Plowman, GD ;

Dey, SK .

DEVELOPMENTAL BIOLOGY, 1997, 190 (02) :178-190

[9]

DAS SK, 1994, DEVELOPMENT, V120, P1071

[10] Peroxisome proliferator-activated receptors: Nuclear control of metabolism [J].

Desvergne, B ;

Wahli, W .

ENDOCRINE REVIEWS, 1999, 20 (05) :649-688

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