Chemistry of the mycalamides: Antiviral and antitumour compounds from a New Zealand marine sponge .6. The synthesis and testing of analogues of the C(7)-C(10) fragment

被引：17

作者：

Abell, AD

Blunt, JW

Foulds, GJ

Munro, MHG

机构：

[1] Department of Chemistry, University of Canterbury, Christchurch

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1997年 / 11期

关键词：

D O I：

10.1039/a608168a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The key structural features associated with the potent cytotoxicity observed in the mycalamide, onnamide, pederin and theopederin series have been defined on the basis of structure-activity studies, A model pharmacophore structure has been proposed and selected examples, with modest bioactivity, synthesized.

引用

页码：1647 / 1654

页数：8

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[2]

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[3]

Bertho A, 1932, LIEBIGS ANN CHEM, V498, P50

[4]

BURRES NS, 1989, CANCER RES, V49, P2935