Detection of estrogen receptor-beta mRNA in breast cancer using RT-PCR

被引：4

作者：

Cullen, R

Maguire, T

Diggin, P

Hill, A

McDermott, E

O'Higgins, NO

Duffy, MJ ^{[1
]}

机构：

[1] St Vincents Univ Hosp, Dept Nucl Med, Dublin 4, Ireland

[2] Univ Coll Dublin, Dept Surg, Dublin 2, Ireland

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS | 2000年 / 15卷 / 01期

关键词：

estrogen receptor-alpha; estrogen receptor-beta; breast cancer; prognosis;

D O I：

10.1177/172460080001500122

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The estrogen receptor (ER) is the most useful marker currently available for breast cancer being used both to predict response to therapy and assess prognosis. Recently, a new form of the ER, known as ER-beta, was identified. In this preliminary study we show that ER-beta mRNA was expressed less frequently in breast cancers than ER-alpha. ER-alpha but not ER-beta levels correlated with ER protein as determined by ELISA. We conclude that ER-beta is expressed in approximately 50% of breast cancers but it does not appear to be detected by a widely available ELISA.

引用

页码：114 / 115

页数：2

共 7 条

[1] Expression of estrogen receptor-beta in human breast tumors [J].