Theory of Free Energy and Entropy in Noncovalent Binding

The theory of noncovalent binding was formulated and interpreted in a number of different ways so as to provide a unified rigorous review of the developed material for intermolecular and intramolecular multivalent binding to bring out important physical implications. The study aims to support the development of well-founded models of binding and the meaningful interpretation of experimental data, that include the changes in translation and other entropy components on binding, the implications of correlation for entropy, and multivalency and the relationship between intramolecular and intermolecular binding. The experiment revealed that the entropy is a property of the whole system that may be partioned in useful and rigorous ways through conditional probability distributions that enables the definition of configurational and solvation entropies.