A Robust Example of Collider Bias in a Genetic Association Study

被引：75

作者：

Day, Felix R. ^{[1
]}

Loh, Po-Ru ^{[2
,3
]}

Scott, Robert A. ^{[1
]}

Ong, Ken K. ^{[1
]}

Perry, John R. B. ^{[1
]}

机构：

[1] Univ Cambridge, Inst Metab Sci, MRC, Epidemiol Unit, Box 285,Hills Rd, Cambridge CB2 0QQ, England

[2] Harvard Univ, TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[3] Broad Inst Harvard & MIT, Program Med & Populat Genet, Cambridge, MA 02142 USA

来源：

AMERICAN JOURNAL OF HUMAN GENETICS | 2016年 / 98卷 / 02期

关键词：

D O I：

10.1016/j.ajhg.2015.12.019

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

引用

页码：392 / 393

页数：2

共 6 条

[1] Adjusting for Heritable Covariates Can Bias Effect Estimates in Genome-Wide Association Studies [J].

Aschard, Hugues ;

Vilhjalmsson, Bjarni J. ;

Joshi, Amit D. ;

Price, Alkes L. ;

Kraft, Peter .

AMERICAN JOURNAL OF HUMAN GENETICS, 2015, 96 (02) :329-339

[2] Efficient Bayesian mixed-model analysis increases association power in large cohorts [J].

Loh, Po-Ru ;

Tucker, George ;

Bulik-Sullivan, Brendan K. ;

Vilhjalmsson, Bjarni J. ;

Finucane, Hilary K. ;

Salem, Rany M. ;

Chasman, Daniel I. ;

Ridker, Paul M. ;

Neale, Benjamin M. ;

Berger, Bonnie ;

Patterson, Nick ;

Price, Alkes L. .

NATURE GENETICS, 2015, 47 (03) :284-+

[3] UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age [J].

Sudlow, Cathie ;

Gallacher, John ;

Allen, Naomi ;

Beral, Valerie ;

Burton, Paul ;

Danesh, John ;

Downey, Paul ;

Elliott, Paul ;

Green, Jane ;

Landray, Martin ;

Liu, Bette ;

Matthews, Paul ;

Ong, Giok ;

Pell, Jill ;

Silman, Alan ;

Young, Alan ;

Sprosen, Tim ;

Peakman, Tim ;

Collins, Rory .

PLOS MEDICINE, 2015, 12 (03)

[4] Why evidence for the fetal origins of adult disease might be a statistical artifact: The "reversal paradox" for the relation between birth weight and blood pressure in later life [J].

Tu, YK ;

West, R ;

Ellison, GTH ;

Gilthorpe, MS .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2005, 161 (01) :27-32

[5] Defining the role of common variation in the genomic and biological architecture of adult human height [J].

Wood, Andrew R. ;

Esko, Tonu ;

Yang, Jian ;

Vedantam, Sailaja ;

Pers, Tune H. ;

Gustafsson, Stefan ;

Chun, Audrey Y. ;

Estrada, Karol ;

Luan, Jian'an ;

Kutalik, Zoltan ;

Amin, Najaf ;

Buchkovich, Martin L. ;

Croteau-Chonka, Damien C. ;

Day, Felix R. ;

Duan, Yanan ;

Fall, Tove ;

Fehrmann, Rudolf ;

Ferreira, Teresa ;

Jackson, Anne U. ;

Karjalainen, Juha ;

Lo, Ken Sin ;

Locke, Adam E. ;

Maegi, Reedik ;

Mihailov, Evelin ;

Porcu, Eleonora ;

Randall, Joshua C. ;

Scherag, Andre ;

Vinkhuyzen, Anna A. E. ;

Westra, Harm-Jan ;

Winkler, Thomas W. ;

Workalemahu, Tsegaselassie ;

Zhao, Jing Hua ;

Absher, Devin ;

Albrecht, Eva ;

Anderson, Denise ;

Baron, Jeffrey ;

Beekman, Marian ;

Demirkan, Ayse ;

Ehret, Georg B. ;

Feenstra, Bjarke ;

Feitosa, Mary F. ;

Fischer, Krista ;

Fraser, Ross M. ;

Goel, Anuj ;

Gong, Jian ;

Justice, Anne E. ;

Kanoni, Stavroula ;

Kleber, Marcus E. ;

Kristiansson, Kati ;

Lim, Unhee .

NATURE GENETICS, 2014, 46 (11) :1173-1186

[6] Association Analysis of 29,956 Individuals Confirms That a Low-Frequency Variant at CCND2 Halves the Risk of Type 2 Diabetes by Enhancing Insulin Secretion [J].

Yaghootkar, Hanieh ;

Stancakova, Alena ;

Freathy, Rachel M. ;

Vangipurapu, Jagadish ;

Weedon, Michael N. ;

Xie, Weijia ;

Wood, Andrew R. ;

Ferrannini, Ele ;

Mari, Andrea ;

Ring, Susan M. ;

Lawlor, Debbie A. ;

Smith, George Davey ;

Jorgensen, Torben ;

Hansen, Torben ;

Pedersen, Oluf ;

Steinthorsdottir, Valgerdur ;

Gudbjartsson, Daniel F. ;

Thorleifsson, Gudmar ;

Thorsteinsdottir, Unnur ;

Stefanssonn, Kari ;

Hattersley, Andrew T. ;

Walker, Mark ;

Morris, Andrew D. ;

McCarthy, Mark I. ;

Palmer, Colin N. A. ;

Laakso, Markku ;

Frayling, Timothy M. .

DIABETES, 2015, 64 (06) :2279-2285

← 1 →