Monte Carlo study of substrate-induced folding and refolding of lattice proteins

被引:22
作者
Coluzza, Ivan
Frenkel, Daan
机构
[1] Univ Cambridge, Ctr Computat Chem, Dept Chem, Cambridge CB2 1EW, England
[2] FOM, Inst Atom & Mol Phys, Amsterdam, Netherlands
关键词
D O I
10.1529/biophysj.106.084236
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Many proteins can switch from one conformation to another under the influence of an external driving force, such as the binding to a specific substrate. Using a simple lattice model we show that it is feasible to design protein-like lattice proteins that can have two different conformations, depending on whether or not they are bound to a substrate. We give three different examples of such substrate-induced refolding. In addition, we have explored substrate-induced folding of lattice proteins that do not fold when free in solution. We show that such proteins can bind with the same high specificity as prefolded protein, but have a considerably lower binding free energy. In this way proteins can bind to a substrate in a way that is highly specific, yet reversible.
引用
收藏
页码:1150 / 1156
页数:7
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