Frailty, Sarcopenia, and Hormones

被引：101

作者：

Morley, John E. ^{[1
]}

Malmstrom, Theodore K. ^{[1
,2
]}

机构：

[1] St Louis Univ, Sch Med, Div Geriatr Med, St Louis, MO 63104 USA

[2] St Louis Univ, Sch Med, Dept Neurol & Psychiat, St Louis, MO 63104 USA

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2013年 / 42卷 / 02期

关键词：

Frailty; Sarcopenia; Hormones; Exercise; CHRONIC HEART-FAILURE; QUALITY-OF-LIFE; SUPPLEMENTATION INCREASES MUSCLE; TESTOSTERONE REPLACEMENT THERAPY; 25-HYDROXYVITAMIN D LEVELS; HUMAN GROWTH-HORMONE; DOUBLE-BLIND; PHYSICAL FUNCTION; OLDER MEN; VITAMIN-D;

D O I：

10.1016/j.ecl.2013.02.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Frailty is now a definable clinical syndrome with a simple screening test. Age-related changes in hormones play a major role in the development of frailty by reducing muscle mass and strength (sarcopenia). Selective Androgen Receptor Molecules and ghrelin agonists are being developed to treat sarcopenia. The role of Activin Type IIB soluble receptors and Follistatin-like 3 mimetics is less certain because of side effects. Exercise (resistance and aerobic), vitamin D and protein supplementation, and reduction of polypharmacy are keys to the treatment of frailty.

引用

页码：391 / +

页数：16

共 142 条

[1] MK-0677 (ibutamoren mesylate) for the treatment of patients recovering from hip fracture: A multicenter, randomized, placebo-controlled phase IIb study [J].

Adunsky, Abraham ;

Chandler, Julie ;

Heyden, Norman ;

Lutkiewicz, Jeannine ;

Scott, Boyd B. ;

Berd, Yuliya ;

Liu, Nancy ;

Papanicolaou, Dimitris A. .

ARCHIVES OF GERONTOLOGY AND GERIATRICS, 2011, 53 (02) :183-189

[2] The impact of social vulnerability on the survival of the fittest older adults [J].

Andrew, Melissa K. ;

Mitnitski, Arnold ;

Kirkland, Susan A. ;

Rockwood, Kenneth .

AGE AND AGEING, 2012, 41 (02) :161-165

[3] Consensus on Cachexia Definitions [J].

Argiles, Josep M. ;

Anker, Stefan D. ;

Evans, William J. ;

Morley, John E. ;

Fearon, Ken C. H. ;

Strasser, Florian ;

Muscaritoli, Maurizio ;

Baracos, Vicky E. .

JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION, 2010, 11 (04) :229-230

[4] A single ascending-dose study of muscle regulator ace-031 in healthy volunteers [J].

Attie, Kenneth M. ;

Borgstein, Niels G. ;

Yang, Yijun ;

Condon, Carolyn H. ;

Wilson, Dawn M. ;

Pearsall, Amelia E. ;

Kumar, Ravi ;

Willins, Debbie A. ;

Seehra, Jas S. ;

Sherman, Matthew L. .

MUSCLE & NERVE, 2013, 47 (03) :416-423

[5] The effects of MK-0677, an oral growth hormone secretagogue, in patients with hip fracture [J].

Bach, MA ;

Rockwood, K ;

Zetterberg, C ;

Thamsborg, G ;

Hébert, R ;

Devogelaer, JP ;

Christiansen, JS ;

Rizzoli, R ;

Ochsner, JL ;

Beisaw, N ;

Gluck, O ;

Yu, L ;

Schwab, T ;

Farrington, J ;

Taylor, AM ;

Ng, J ;

Fuh, V .

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2004, 52 (04) :516-523

[6] Low nutrient intake is an essential component of frailty in older persons [J].

Bartali, Benedetta ;

Frongillo, Edward A. ;

Bandinelli, Stefania ;

Lauretani, Fulvio ;

Semba, Richard D. ;

Fried, Linda P. ;

Ferrucci, Luigi .

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2006, 61 (06) :589-593

[7] Sarcopenia in Nursing Home Residents [J].

Bauer, Juergen M. ;

Kaiser, M. J. ;

Sieber, Cornel C. .

JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION, 2008, 9 (08) :545-551

[8] Predictors of skeletal muscle mass in elderly men and women [J].

Baumgartner, RN ;

Waters, DL ;

Gallagher, D ;

Morley, JE ;

Garry, PJ .

MECHANISMS OF AGEING AND DEVELOPMENT, 1999, 107 (02) :123-136

[9]

Baylis D, 2012, AGE DORDR

[10] Recombinant human insulin-like growth factor I (rhIGF-I) for the treatment of amyotrophic lateral sclerosis/motor neuron disease [J].

Beauverd, Michel ;

Mitchell, J. D. ;

Wokke, John H. J. ;

Borasio, Gian Domenico .

COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2012, (11)

← 1 2 3 4 5 6 7 8 9 10 →