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Clinical trials in spinal cord injury

被引：29
作者：
Blight, AR
Tuszynski, MH [1 ]
机构：
[1] Univ Calif San Diego, Ctr Neural Repair, La Jolla, CA 92093 USA
[2] Acorda Therapeut, Hawthorne, CA USA
[3] Vet Adm Med Ctr, La Jolla, CA 90034 USA
来源：
JOURNAL OF NEUROTRAUMA | 2006年 / 23卷 / 3-4期
关键词：
clinical trials; human clinical trial design and performance; spinal cord injury; translational research;
D O I：
10.1089/neu.2006.23.586
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
Progress in promoting axonal plasticity and regeneration in animal models of spinal cord injury (SCI) has led to novel prospects for the initiation of human clinical trials in the near future. This review discusses a number of considerations in the path to translating a preclinical candidate from the laboratory to clinical testing. We will also briefly discuss issues associated with the design, performance, analysis, and reporting of human clinical trials in SCI. It is important, for both the medical community and the spinal cord injured community, that objective scientific and medical standards are adopted in the clinical translation of potentially promising, but as yet unproven, therapies for SCI.
引用
收藏
页码：586 / 593
页数：8
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