Immunogenicity and impact on nasopharyngeal carriage of a nonavalent pneumococcal conjugate vaccine

被引:406
作者
Mbelle, N
Heubner, RE
Wasas, AD
Kimura, A
Chang, I
Klugman, KP
机构
[1] S African Inst Med Res, MRC SAIMR WITS Pneumococcal Dis Res Unit, ZA-2000 Johannesburg, South Africa
[2] Wyeth Lederle Vaccines & Pediat, W Henrietta, NY USA
关键词
D O I
10.1086/315009
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The safety, immunogenicity, and impact on carriage of a nonvalent pneumococcal vaccine given at ages 6, 10, and 14 weeks were examined in a double-blind, randomized, placebo-controlled trial in 500 infants in Soweto, South Africa. No serious local or systemic side effects were recorded. Significant antibody responses to all pneumococcal serotypes were observed 4 weeks after the third dose. Haemophilus influenzae type b polyribosylribitol phosphate (geometric mean titer, 11.62 mu g/mL) and diphtheria (1.39 IU/mL) antibodies were significantly higher in children receiving pneumococcal conjugate, compared with placebo recipients (4.58 mu g/mL and 0.98 IU/mL, respectively). Nasopharyngeal carriage of vaccine serotypes decreased in vaccinees at age 9 months (18% vs. 36%), whereas carriage of nonvaccine serotypes increased (36% vs. 25%), Carriage of penicillin-resistant pneumococci (21% vs, 41%) and cotrimoxazole-resistant pneumococci (23% vs. 35%) were significantly reduced 9 months after vaccination, compared with controls.
引用
收藏
页码:1171 / 1176
页数:6
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