In vivo inhibition of osteoblastic metalloproteinases leads to increased trabecular bone mass

被引：56

作者：

Geoffroy, V

Marty-Morieux, C

Le Goupil, N

Clement-Lacroix, P

Terraz, C

Frain, M

Roux, S

Rossert, K

De Vernejoul, MC

机构：

[1] Hop Lariboisiere, INSERM, U 349, F-75475 Paris 10, France

[2] Proskelia, Romainville, France

[3] Hop Tenon, INSERM, U 489, F-75970 Paris, France

[4] Ecole Normale Super, INSERM, U 368, F-75231 Paris, France

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2004年 / 19卷 / 05期

关键词：

matrix metalloproteinases; extracellular matrix; osteoblast function; low bone turnover; mouse model;

D O I：

10.1359/JBMR.040119

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mice specifically overexpressing TIMP-1 in osteoblasts have been generated to investigate the role of MMPs in bone in vivo. These mice displayed increased trabecular bone volume and decreased bone turnover. This model provides evidence of the role played by the MMPs in bone remodeling and balance.

引用

收藏

页码：811 / 822

页数：12

相关论文

共 50 条

[1] TIMP-1 overexpression in pancreatic cancer attenuates tumor growth, decreases implantation and metastasis, and inhibits angiogenesis [J].

Bloomston, M ;

Shafii, S ;

Zervos, EE ;

Rosemurgy, AS .

JOURNAL OF SURGICAL RESEARCH, 2002, 102 (01) :39-44

[2] Alendronate increases bone strength by increasing the mean degree of mineralization of bone tissue in osteoporotic women [J].

Boivin, GY ;

Chavassieux, PM ;

Santora, AC ;

Yates, J ;

Meunier, PJ .

BONE, 2000, 27 (05) :687-694

[3] Tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) distribution in normal and pathological human bone [J].

Bord, S ;

Horner, A ;

Beeton, CA ;

Hembry, RM ;

Compston, JE .

BONE, 1999, 24 (03) :229-235

[4] Stromelysin (MMP-3) synthesis is up-regulated in estrogen-deficient mouse osteoblasts in vivo and in vitro [J].

Breckon, JJW ;

Papaioannou, S ;

Kon, LWM ;

Tumber, A ;

Hembry, RM ;

Murphy, G ;

Reynolds, JJ ;

Meikle, MC .

JOURNAL OF BONE AND MINERAL RESEARCH, 1999, 14 (11) :1880-1890

[5]

CHAMBERS TJ, 1985, CELL TISSUE RES, V241, P671

[6] Proteinases in bone resorption:: obvious and less obvious roles [J].

Delaissé, JM ;

Engsig, MT ;

Everts, V ;

Ovejero, MD ;

Ferreras, M ;

Lund, L ;

Vu, TH ;

Werb, Z ;

Winding, B ;

Lochter, A ;

Karsdal, MA ;

Troen, T ;

Kirkegaard, T ;

Lenhard, T ;

Heegaard, AM ;

Neff, L ;

Baron, R ;

Foged, NT .

CLINICA CHIMICA ACTA, 2000, 291 (02) :223-234

[7] Localisation of matrix metalloproteinases and TIMP-2 in resorbing mouse bone [J].

Dew, G ;

Murphy, G ;

Stanton, H ;

Vallon, R ;

Angel, P ;

Reynolds, JJ ;

Hembry, RM .

CELL AND TISSUE RESEARCH, 2000, 299 (03) :385-394

[8] MMP inhibitors: Glimmers of hope amidst clinical failures [J].

Dove, A .

NATURE MEDICINE, 2002, 8 (02) :95-95

[9] Cathepsin K, but not cathepsins B, L, or S, is abundantly expressed in human osteoclasts [J].

Drake, FH ;

Dodds, RA ;

James, IE ;

Connor, JR ;

Debouck, C ;

Richardson, S ;

LeeRykaczewski, E ;

Coleman, L ;

Rieman, D ;

Barthlow, R ;

Hastings, G ;

Gowen, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (21) :12511-12516

[10] Body composition, bone mass and microstructural analysis in GH-transgenic mice reveals that skeletal changes are specific to bone compartment and gender [J].

Eckstein, F ;

Lochmüller, EM ;

Koller, B ;

Wehr, U ;

Weusten, A ;

Rambeck, W ;

Hoeflich, A ;

Wolf, E .

GROWTH HORMONE & IGF RESEARCH, 2002, 12 (02) :116-125

← 1 2 3 4 5 →