New latent fluorophore for DT diaphorase

被引：43

作者：

Huang, ST ^{[1
]}

Lin, YL

机构：

[1] Natl Taipei Univ Technol, Dept Chem Engn & Biotechnol, Coll Engn, Taipei 106, Taiwan

[2] Fu Jen Catholic Univ, Coll Med, Dept Med, Taipei 24205, Taiwan

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 02期

关键词：

D O I：

10.1021/ol052635e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This study describes the design and synthesis of a novel latent fluorophore 3 for DT diaphorase based on the trimethyl lock effect and characterization of its enzymatic kinetics. Fluorophore 3 is also a sensitive fluorimetric reagent for detecting glucose when coupled with DTD and glucose dehydrogenase.

引用

页码：265 / 268

页数：4

共 27 条

[1] STEREOPOPULATION CONTROL .3. FACILITATION OF INTRAMOLECULAR CONJUGATE ADDITION OF CARBOXYL GROUP [J].

BORCHARD.RT ;

COHEN, LA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1972, 94 (26) :9175-9182

[2] Latent fluorophore based on the trimethyl lock [J].

Chandran, SS ;

Dickson, KA ;

Raines, RT .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (06) :1652-1653

[3] A selective, cell-permeable optical probe for hydrogen peroxide in living cells [J].

Chang, MCY ;

Pralle, A ;

Isacoff, EY ;

Chang, CJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (47) :15392-15393

[4]

Ernster L, 1967, Methods in enzymology, P309, DOI DOI 10.1016/0076-6879(67)10059-1

[5] Targeted drug delivery systems 6. Intracellular bioreductive activation, uptake and transport of an anticancer drug delivery system across intestinal Caco-2 cell monolayers [J].

Gharat, L ;

Taneja, R ;

Weerapreeyakul, N ;

Rege, B ;

Polli, J ;

Chikhale, PJ .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2001, 219 (1-2) :1-10

[6] The role of NAD(P)H oxidoreductase (DT-diaphorase) in the bioactivation of quinone-containing antitumor agents: A review [J].

Gutierrez, PL .

FREE RADICAL BIOLOGY AND MEDICINE, 2000, 29 (3-4) :263-275

[7] PURIFIED NAD(P)H-QUINONE OXIDOREDUCTASE ENHANCES THE MUTAGENICITY OF DINITROPYRENES INVITRO [J].

HAJOS, AKD ;

WINSTON, GW .

JOURNAL OF BIOCHEMICAL TOXICOLOGY, 1991, 6 (04) :277-282

[8] Cross-linking and sequence specific alkylation of DNA by aziridinyl quinones .2. Structure requirements for sequence selectivity [J].

Hargreaves, RHJ ;

Mayalarp, SP ;

Butler, J ;

McAdam, SR ;

OHare, CC ;

Hartley, JA .

JOURNAL OF MEDICINAL CHEMISTRY, 1997, 40 (03) :357-361

[9]

Haughland R.P., 1996, HDB FLUORESCENT PROB

[10]

HOSODA S, 1974, J BIOL CHEM, V249, P6416

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