Very-high-dose phenobarbital for childhood refractory status epilepticus
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作者:
Lee, WK
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Pamela Youde Nethersole Eastern Hosp, Dept Paediat & Adolescent Med, Hong Kong, Hong Kong, Peoples R ChinaPamela Youde Nethersole Eastern Hosp, Dept Paediat & Adolescent Med, Hong Kong, Hong Kong, Peoples R China
Lee, WK
[1
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Liu, KT
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Pamela Youde Nethersole Eastern Hosp, Dept Paediat & Adolescent Med, Hong Kong, Hong Kong, Peoples R ChinaPamela Youde Nethersole Eastern Hosp, Dept Paediat & Adolescent Med, Hong Kong, Hong Kong, Peoples R China
Liu, KT
[1
]
Young, BWY
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Pamela Youde Nethersole Eastern Hosp, Dept Paediat & Adolescent Med, Hong Kong, Hong Kong, Peoples R ChinaPamela Youde Nethersole Eastern Hosp, Dept Paediat & Adolescent Med, Hong Kong, Hong Kong, Peoples R China
Young, BWY
[1
]
机构:
[1] Pamela Youde Nethersole Eastern Hosp, Dept Paediat & Adolescent Med, Hong Kong, Hong Kong, Peoples R China
This report describes the management of three children, ranging in age from 7 to 9 years, who had refractory status epilepticus. This condition was likely the result of viral encephalitis; it manifested initially as generalized tonic-clonic seizure and later frequent subtle eye staring and twitching of mouth or limbs as well as tachycardia and dilatation of pupils. The seizures were not responsive to treatment with conventional doses of intravenous phenobarbital, phenytoin, and midazolam infusion. Very-high-dose phenobarbital was administered at accumulated daily doses up to 80 mg/kg, with a resulting serum level of more than 1000 mu mol/L. It was effective in achieving seizure control, with milder adverse effects compared with thiopental infusion. (c) 2006 by Elsevier Inc. All rights reserved.
机构:
Schneider Childrens Hosp, Long Isl Jewish Med Ctr, Div Crit Care Med, New Hyde Pk, NY 11040 USASchneider Childrens Hosp, Long Isl Jewish Med Ctr, Div Crit Care Med, New Hyde Pk, NY 11040 USA
Igartua, J
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Silver, P
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机构:Schneider Childrens Hosp, Long Isl Jewish Med Ctr, Div Crit Care Med, New Hyde Pk, NY 11040 USA
Silver, P
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Maytal, J
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机构:Schneider Childrens Hosp, Long Isl Jewish Med Ctr, Div Crit Care Med, New Hyde Pk, NY 11040 USA
Maytal, J
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Sagy, M
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机构:Schneider Childrens Hosp, Long Isl Jewish Med Ctr, Div Crit Care Med, New Hyde Pk, NY 11040 USA
机构:
Great Ormond St Hosp Sick Children, Inst Child Hlth, UCLMS, London WC1N 3JH, EnglandGreat Ormond St Hosp Sick Children, Inst Child Hlth, UCLMS, London WC1N 3JH, England
Scott, RC
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Neville, BGR
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Great Ormond St Hosp Sick Children, Inst Child Hlth, UCLMS, London WC1N 3JH, EnglandGreat Ormond St Hosp Sick Children, Inst Child Hlth, UCLMS, London WC1N 3JH, England
机构:
Schneider Childrens Hosp, Long Isl Jewish Med Ctr, Div Crit Care Med, New Hyde Pk, NY 11040 USASchneider Childrens Hosp, Long Isl Jewish Med Ctr, Div Crit Care Med, New Hyde Pk, NY 11040 USA
Igartua, J
;
Silver, P
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机构:Schneider Childrens Hosp, Long Isl Jewish Med Ctr, Div Crit Care Med, New Hyde Pk, NY 11040 USA
Silver, P
;
Maytal, J
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机构:Schneider Childrens Hosp, Long Isl Jewish Med Ctr, Div Crit Care Med, New Hyde Pk, NY 11040 USA
Maytal, J
;
Sagy, M
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机构:Schneider Childrens Hosp, Long Isl Jewish Med Ctr, Div Crit Care Med, New Hyde Pk, NY 11040 USA
机构:
Great Ormond St Hosp Sick Children, Inst Child Hlth, UCLMS, London WC1N 3JH, EnglandGreat Ormond St Hosp Sick Children, Inst Child Hlth, UCLMS, London WC1N 3JH, England
Scott, RC
;
Neville, BGR
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Great Ormond St Hosp Sick Children, Inst Child Hlth, UCLMS, London WC1N 3JH, EnglandGreat Ormond St Hosp Sick Children, Inst Child Hlth, UCLMS, London WC1N 3JH, England