Very-high-dose phenobarbital for childhood refractory status epilepticus

被引:31
作者
Lee, WK [1 ]
Liu, KT [1 ]
Young, BWY [1 ]
机构
[1] Pamela Youde Nethersole Eastern Hosp, Dept Paediat & Adolescent Med, Hong Kong, Hong Kong, Peoples R China
关键词
D O I
10.1016/j.pediatrneurol.2005.06.014
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
This report describes the management of three children, ranging in age from 7 to 9 years, who had refractory status epilepticus. This condition was likely the result of viral encephalitis; it manifested initially as generalized tonic-clonic seizure and later frequent subtle eye staring and twitching of mouth or limbs as well as tachycardia and dilatation of pupils. The seizures were not responsive to treatment with conventional doses of intravenous phenobarbital, phenytoin, and midazolam infusion. Very-high-dose phenobarbital was administered at accumulated daily doses up to 80 mg/kg, with a resulting serum level of more than 1000 mu mol/L. It was effective in achieving seizure control, with milder adverse effects compared with thiopental infusion. (c) 2006 by Elsevier Inc. All rights reserved.
引用
收藏
页码:63 / 65
页数:3
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