Integrated THz technology for label-free genetic diagnostics

被引:461
作者
Nagel, M
Bolivar, PH
Brucherseifer, M
Kurz, H
Bosserhoff, A
Büttner, R
机构
[1] Rhein Westfal TH Aachen, Inst Halbleitertech, D-52056 Aachen, Germany
[2] Rhein Westfal TH Aachen, Inst Pathol, D-52074 Aachen, Germany
关键词
D O I
10.1063/1.1428619
中图分类号
O59 [应用物理学];
学科分类号
摘要
We report on a promising approach for the label-free analysis of DNA molecules using direct probing of the binding state of DNA with electromagnetic waves at THz frequencies. Passive THz resonator devices based on planar waveguides are used as sample carriers and transducers for THz transmission analysis. In comparison to a formerly used free-space detection scheme, this method provides a drastically enhanced sensitivity enabling analysis down to femtomol levels. We examine the potential of our approach on biologically relevant DNA samples and demonstrate the detection of single base mutations on DNA molecules. (C) 2002 American Institute of Physics.
引用
收藏
页码:154 / 156
页数:3
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