Changes in malaria indices between 1999 and 2007 in The Gambia: a retrospective analysis

被引：311

作者：

Ceesay, Serign J. ^{[1
]}

Casals-Pascual, Climent ^{[1
]}

Erskine, Jamie ^{[2
]}

Anya, Samuel E. ^{[3
,4
]}

Duah, Nancy O. ^{[1
]}

Fulford, Anthony J. C. ^{[1
,5
]}

Sesay, Sanie S. S. ^{[1
]}

Abubakar, Ismaela ^{[1
]}

Dunyo, Samuel ^{[1
]}

Sey, Omar ^{[6
]}

Palmer, Ayo ^{[4
]}

Fofana, Malang ^{[7
]}

Corrah, Tumani ^{[1
]}

Bojang, Kalifa A. ^{[1
]}

Whittle, Hilton C. ^{[1
]}

Greenwood, Brian M. ^{[5
]}

Conway, David J. ^{[1
,5
]}

机构：

[1] MRC Labs, Banjul, Gambia

[2] WEC Mission Hosp, Sibanor, Western Region, Gambia

[3] Univ Gambia, Sch Med & Allied Hlth Sci, Kanifing, Gambia

[4] CIAM Publ Hlth Res & Dev Ctr, Kanifing, Gambia

[5] Univ London London Sch Hyg & Trop Med, London WC1E 7HT, England

[6] AFPRC Farafenni Hosp, N Bank Region, Gambia

[7] NMCP, Banjul, Gambia

来源：

LANCET | 2008年 / 372卷 / 9649期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0140-6736(08)61654-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background Malaria is a major cause of morbidity and mortality in Africa. International effort and funding for control has been stepped up, with substantial increases from 2003 in the delivery of malaria interventions to pregnant women and children younger than 5 years in The Gambia. We investigated the changes in malaria indices in this country, and the causes and public-health significance of these changes. Methods We undertook a retrospective analysis of original records to establish numbers and proportions of malaria inpatients, deaths, and blood-slide examinations at one hospital over 9 years (January, 1999-December, 2007), and at four health facilities in three different administrative regions over 7 years (January, 2001-December, 2007). We obtained additional data from single sites for haernoglobin concentrations in paediatric admissions and for age distribution of malaria admissions. Findings From 2003 to 2007, at four sites with complete slide examination records, the proportions of malaria-positive slides decreased by 82% (3397/10861 in 2003 to 337/6142 in 2007), 85% (137/1259 to 6/368), 73% (3664/16932 to 666/11333), and 50% (1206/3304 to 336/1853). At three sites with complete admission records, the proportions of malaria admissions fell by 74% (435/2530 to 69/1531), 69% (797/2824 to 89/1032), and 27% (2204/4056 to 496/1251.). Proportions of deaths attributed to malaria in two hospitals decreased by 100% (seven of 115 in 2003 to none of 117 in 2007) and 90% (22/122 in 2003 to one of 58 in 2007). Since 2004, mean haemoglobin concentrations for all-cause admissions increased by 12 g/L (85 g/L in 2000-04 to 97 g/L in 2005-07), and mean age of paediatric malaria admissions increased from 3.9 years (95% CI 3.7-4 . 0) to 5.6 years (5.0-6.2). Interpretation A large proportion of the malaria burden has been alleviated in The Gambia. Our results encourage consideration of a policy to eliminate malaria as a public-health problem, while emphasising the importance of accurate and continuous surveillance. Funding UK Medical Research Council,

引用

页码：1545 / 1554

页数：10

共 41 条

[1] THE EFFECT OF INSECTICIDE-TREATED BED NETS ON MORTALITY OF GAMBIAN CHILDREN [J].