Asymmetric synthesis of L-cyclopentyl carbocyclic nucleosides

被引：29

作者：

Wang, PY ^{[1
]}

Agrofoglio, LA ^{[1
]}

Newton, MG ^{[1
]}

Chu, CK ^{[1
]}

机构：

[1] UNIV GEORGIA,DEPT CHEM,ATHENS,GA 30602

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 24期

关键词：

D O I：

10.1016/S0040-4039(97)00898-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Asymmetric synthesis of L-carbocyclic nucleosides, (+)-beta-L-aristeromycin (11) and its thymine analog (12) was accomplished. The key intermediate 3 was synthesized by a regioselective conjugate addition to the enone 1 followed by DIBAL-H reduction. Coupling of 4 with heterocycle or construction of heterocyle by a linear approach gave 11 and 12. This is the first asymmetric synthesis of L-cyclopentyl carbocyclic nucleosides. (C) 1997 Elsevier Science Ltd.

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页码：4207 / 4210

页数：4

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