Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment

被引：345

作者：

Meshi, Dar

Drew, Michael R.

Saxe, Michael

Ansorge, Mark S.

David, Denis

Santarelli, Luca

Malapani, Chariklia

Moore, Holly

Hen, Rene

机构：

[1] Columbia Univ, Ctr Neurobiol & Behav, New York, NY 10032 USA

[2] Columbia Univ, Dept Biol Sci, New York, NY 10027 USA

[3] New York State Psychiat Inst & Hosp, Biopsychol Unit, New York, NY 10032 USA

[4] Columbia Univ, Dept Psychiat, New York, NY 10032 USA

[5] Univ Paris Sud, Fac Pharm, F-92296 Chatenay Malabry, France

来源：

NATURE NEUROSCIENCE | 2006年 / 9卷 / 06期

关键词：

D O I：

10.1038/nn1696

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Environmental enrichment increases adult hippocampal neurogenesis and alters hippocampal-dependent behavior in rodents. To investigate a causal link between these two observations, we analyzed the effect of enrichment on spatial learning and anxiety-like behavior while blocking adult hippocampal neurogenesis. We report that environmental enrichment alters behavior in mice regardless of their hippocampal neurogenic capability, providing evidence that the newborn cells do not mediate these effects of enrichment.

引用

页码：729 / 731

页数：3

共 16 条

[1]

[Anonymous], 2000, NEUROPSYCHOLOGY ANXI

[2] Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis [J].