T-loops and the origin of telomeres

被引：316

作者：

de Lange, T ^{[1
]}

机构：

[1] Rockefeller Univ, Cell Biol & Genet Lab, New York, NY 10021 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2004年 / 5卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrm1359

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Most eukaryotes stabilize the ends of their linear chromosomes with a telomerase-based system. Telomerase maintains specific repetitive sequences, which protect chromosome ends with the help of telomere-binding proteins. How did this elaborate system evolve? Here, I propose that telomere function was originally mediated by t-loops, which could have been generated by prokaryotic DNA-replication factors. These early telomeres would have required only the presence of a few repeats at chromosome ends. Telomerase could have been a later innovation with specific advantages for telomere function and regulation.

引用

页码：323 / 329

页数：8

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