Apoptotic signaling pathways: Caspases and stress-activated protein kinases

被引:172
作者
Cho, SG [1 ]
Choi, EJ [1 ]
机构
[1] Korea Univ, Natl Creat Res Initiat Ctr Cell Death, Grad Sch Biotechnol, Seoul 136701, South Korea
来源
JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2002年 / 35卷 / 01期
关键词
apoptosis; caspases; stress-activated protein kinases;
D O I
10.5483/BMBRep.2002.35.1.024
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Apoptotic cell death is an active process mediated by various signaling pathways, which include the caspase cascade and the stress-activated protein kinase pathways. The caspase cascade is activated by two distinct routes: one from cell surface and the other from mitochondria. Activation of the route from cell surface requires the cellular components that include membrane receptors, adaptor proteins such as TRADD and FADD, and caspase-8, while activation of the other from mitochondria requires Apaf-1, caspase-9, and cytosolic cytochrome c. On the other hand, persistent stimulation of the stress-activated protein kinase pathway is also shown to mediate apoptosis; in many cell types. Gene-targeting studies with jnk- or jip-null mice, in particular, strongly suggest that this signaling pathway plays a pivotal role in the cellular machinery for apoptosis.
引用
收藏
页码:24 / 27
页数:4
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