Estrogen and Its Receptors in Cancer

被引：177

作者：

Chen, George G. ^{[1
]}

Zeng, Qiang ^{[1
]}

Tse, Gary M. K. ^{[2
]}

机构：

[1] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Surg, Shatin, Hong Kong, Peoples R China

[2] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Anat & Cellular Pathol, Shatin, Hong Kong, Peoples R China

来源：

MEDICINAL RESEARCH REVIEWS | 2008年 / 28卷 / 06期

关键词：

estrogen; estrogen receptor; cancer;

D O I：

10.1002/med.20131

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The involvement of estrogen and its receptors in the development of cancer has been known for years. However, the exact mechanism responsible is far from clear. The estrogen-mediated carcinogenic process is complicated by recent findings, which reveal that estrogens have multiple functions in cells, which can be either adverse or beneficial, and that the effects of estrogen may be cell-type or organ dependent. The estrogenic effect may be also greatly influenced by the state of two estrogen receptors, ER alpha and ER beta. This review will discuss the role and function of estrogens and its receptors in cancers of three categories: (1) Breast cancer and gynecologic cancers, (2) Cancers of endocrine organs, (3) Lung cancer and cancers of digestive system. We will also review some novel treatments aiming to interfere with relevant pathways mediated by estrogens and its receptors. (C) 2008 Wiley Periodicals, Inc. Med Res Rev, 28, No. 6, 954-974, 2008

引用

页码：954 / 974

页数：21

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