Surface-modified magnetite nanoparticles for hyperthermia: Preparation, characterization, and cytotoxicity studies

被引:79
作者
Kim, D. H. [1 ,2 ]
Lee, S. H. [1 ,2 ]
Im, K. H. [1 ,2 ]
Kim, K. N. [1 ,2 ]
Kim, K. M. [1 ,2 ]
Shim, I. B. [3 ]
Lee, M. H. [4 ]
Lee, Y. -K. [1 ,2 ]
机构
[1] Yonsei Univ, Coll Dent, Brain Korea Project Med Sci 21, Seoul 120752, South Korea
[2] Yonsei Univ, Coll Dent, Dept & Res Inst Dent Biomat & Bioengn, Seoul 120752, South Korea
[3] Kookmin Univ, Dept Phys Elect, Seoul, South Korea
[4] Korea Inst Ceram Engn & Technol, Seoul, South Korea
关键词
Nano-magnetite; Hyperthermia; Hysteresis loss; AC magnetic field; MTT assay;
D O I
10.1016/j.cap.2006.01.048
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
Biocompatible magnetic nanoparticles could be selected for smart hyperthermia. The magnetic particles should have a narrow size distribution and surface modified with biocompatible materials. In this study, the effects of surface modification in nano-magnetite were evaluated by characterization and cell response. The synthesized magnetite exhibited a mean diameter of 10.3 +/- 2.6 nm. The temperature change under alternating magnetic field and saturation magnetization (M-s) was Delta T = 23 degrees C, M-s = 25.6 emu/g and Delta T = 12 degrees C, M-s = 16.4 emu/g in chitosan and starch coated magnetite, respectively. In cytotoxic test, the viability of L929 cells was the greatest value 93.67% in chitosan coated magnetic particles. The exothermic and biocompatible chitosan coated magnetite will be selected for optimized hyperthermic thermoseed. (C) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码:E242 / E246
页数:5
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