Clonal interference and the evolution of RNA viruses

被引:209
作者
Miralles, R
Gerrish, PJ
Moya, A
Elena, SF
机构
[1] Univ Valencia, Inst Cavanilles Biodiversitat & Biol Evolut, Valencia 46071, Spain
[2] Univ Valencia, Dept Genet, Valencia 46071, Spain
[3] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA
关键词
D O I
10.1126/science.285.5434.1745
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
In asexual populations, beneficial mutations that occur in different lineages compete with one another. This phenomenon, known as clonal interference, ensures that those beneficial mutations that do achieve fixation are of Large effect. Clonal interference also increases the time between fixations, thereby stowing the adaptation of asexual populations. The effects of clonal interference were measured in the asexual RNA virus vesicular stomatitis virus; rates and average effects of beneficial mutations were quantified.
引用
收藏
页码:1745 / 1747
页数:3
相关论文
共 23 条
[1]  
Burch CL, 1999, GENETICS, V151, P921
[2]  
Craig A. T., 1995, INTRO MATH STAT
[3]  
CROW JAMES F., 1965, AMER NATUR, V99, P439, DOI 10.1086/282389
[4]   Diminishing returns from mutation supply rate in asexual populations [J].
de Visser, JAGM ;
Zeyl, CW ;
Gerrish, PJ ;
Blanchard, JL ;
Lenski, RE .
SCIENCE, 1999, 283 (5400) :404-406
[5]   RNA VIRUS QUASISPECIES POPULATIONS CAN SUPPRESS VASTLY SUPERIOR MUTANT PROGENY [J].
DELATORRE, JC ;
HOLLAND, JJ .
JOURNAL OF VIROLOGY, 1990, 64 (12) :6278-6281
[6]  
Drake JW, 1998, GENETICS, V148, P1667
[7]   RATES OF SPONTANEOUS MUTATION AMONG RNA VIRUSES [J].
DRAKE, JW .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (09) :4171-4175
[8]  
Elena SF, 1998, EVOLUTION, V52, P309, DOI 10.1111/j.1558-5646.1998.tb01633.x
[9]   Multiple molecular pathways for fitness recovery of an RNA virus debilitated by operation of Muller's ratchet [J].
Escarmís, C ;
Dávila, M ;
Domingo, E .
JOURNAL OF MOLECULAR BIOLOGY, 1999, 285 (02) :495-505
[10]  
Fisher R. A., 1999, The Genetical Theory of Natural Selection: A Complete Variorum Edition