Lack of association between seropositivity to Chlamydia pneumoniae and carotid atherosclerosis

被引:44
作者
Coles, KA [1 ]
Plant, AJ
Riley, TV
Smith, DW
McQuillan, BM
Thompson, PL
机构
[1] Univ Western Australia, Dept Publ Hlth, Nedlands, WA 6009, Australia
[2] Univ Western Australia, Dept Microbiol, Nedlands, WA 6009, Australia
[3] Univ Western Australia, Dept Med, Nedlands, WA 6009, Australia
[4] Sir Charles Gairdner Hosp, Ctr Pathol & Med Res & Cardiovasc Med, Perth, WA, Australia
关键词
D O I
10.1016/S0002-9149(99)00445-2
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Since the Chlamydia pneumoniae (C. pneumoniae)-specific antibody was shown to be associated with acute myocardial infarction and chronic coronary heart disease, the role of C. pneumoniae in the etiology of cardiovascular disease has been studied by a number of groups. We investigated the association between the C. pneumoniae-specific antibody, measured by microimmunofluorescence, risk factors for cardiovascular disease, and atherosclerosis in a randomly selected urban population, Overall, immunoglobulin-G (IgG) seroprevalence:to C. pneumoniae in this sample of 1,034 subjects was 58%, whereas IgA seroprevalence was 32%. There was a decline in seropositivity with age for IgG but not IgA. Men were more likely than women to be IgG (66% vs 51%, chi-square p = 0.001) and IgA seropositive (36% vs 28%, chi-square p = 0.005). Current smokers had higher IgA seropositivity than nonsmokers (43% vs 30%), Those patients with a family history of cerebrovascular disease were more likely to have IgG antibody than those without (75% vs 57%, chi-square p = 0.007). Neither IgG nor IgA seropositivity was associated with the standard risk factors of hypertension, hyperlipidemia, or family history of ischemic heart disease, nor was seropositivity associated with carotid intima medial thickening (IMT) or atherosclerotic plaque as measured by carotid B-mode ultrasound. There was no difference between those participants who were IgG or IgA seropositive and seronegative in measurements of mean IMT, prevalence of abnormal IMT, and percentage with atherosclerotic plaque. In conclusion, although C, pneumoniae was associated with several risk factors for cardiovascular disease in a large cross-sectional population, we found no independent association between seroprevalence to C, pneumoniae and carotid atherosclerosis as measured by carotid IMT. (C)1999 by Excerpta Medica, Inc.
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收藏
页码:825 / 828
页数:4
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