Permeation dynamics of chloride ions in the CIC-0 and CIC-1 channels

被引：7

作者：

Corry, B ^{[1
]}

O'Mara, M ^{[1
]}

Chung, SH ^{[1
]}

机构：

[1] Australian Natl Univ, Res Sch Phys Sci & Engn, Dept Theoret Phys, Canberra, ACT 0200, Australia

来源：

CHEMICAL PHYSICS LETTERS | 2004年 / 386卷 / 4-6期

基金：

英国医学研究理事会; 澳大利亚研究理事会;

关键词：

D O I：

10.1016/j.cplett.2004.01.072

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

We examine the mechanisms underlying the transport of ions across ClC-0 and ClC-1, the two best characterized members of the ubiquitous ClC chloride channel family. Using molecular and Brownian dynamics techniques we create an open channel structure, deduce the permeation characteristics, and highlight the amino acid residues responsible for the different conductance properties of these channels. (C) 2003 Elsevier B.V. All rights reserved.

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页码：233 / 238

页数：6

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