Risperidone treatment of children and adolescents with developmental disorders

被引：62

作者：

Hardan, A

Johnson, K

Johnson, C

Hrecznyj, B

机构：

[1] John Merck Multiple Disabil. Program, W. Psychiatric Institute and Clinic, Univ. of Pittsburgh Medical Center, Pittsburgh

[2] W. Psychiatric Institute and Clinic, Pittsburgh, PA 15213

来源：

JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY | 1996年 / 35卷 / 11期

关键词：

risperidone; children and adolescents; developmental disorders;

D O I：

10.1097/00004583-199611000-00025

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

In a clinical trial, 20 children and adolescents with developmental disorders (age range 8 through 17 years) refractory to previous psychotropic treatments were administered the atypical neuroleptic risperidone (dose range 1.5 to 10 mg/day). In a follow-up period ranging from 8 to 15 months, risperidone demonstrated clinical efficacy in 13 children. Twelve patients were free of side effects and two had minor ones. Three patients had marked weight increase, and galactorrhea developed in two adolescent girls. In this open study, risperidone was associated with clinical improvement. However, controlled studies are needed to determine its relative efficacy and safety in this special population.

引用

页码：1551 / 1556

页数：6

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