The mitochondrial complex I: Progress in understanding of catalytic properties

被引：57

作者：

Vinogradov, AD ^{[1
]}

Grivennikova, VG ^{[1
]}

机构：

[1] Moscow MV Lomonosov State Univ, Sch Biol, Dept Biochem, Moscow 119899, Russia

来源：

IUBMB LIFE | 2001年 / 52卷 / 3-5期

关键词：

NADH : ubiquinone oxidoreductase; electron transfer; respiratory chain;

D O I：

10.1080/15216540152845920

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although the mitochondrial Complex I has been extensively studied for over 4 decades, its catalytic properties in mitochondria are poorly understood. This review summarizes the data on standard and nonstandard kinetic parameters of the enzyme. The slow interconversion between active and deactivated forms of the mammalian Complex I (A/D transition) is described. We discuss the potential relevance of this transition for the regulation of NADH oxidation by the respiratory chain under physiological and pathophysiological conditions.

引用

页码：129 / 134

页数：6

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