Short report:: Lipopolysaccharide heterogeneity among Burkholderia pseudomallei from different geographic and clinical origins

被引：49

作者：

Anuntagool, N

Wuthiekanun, V

White, NJ

Currie, BJ

Sermswan, RW

Wongratanacheewin, S

Taweechaisupapong, S

Chaiyaroj, SC

Strisinha, S

机构：

[1] Mahidol Univ, Fac Trop Med, Bangkok 10400, Thailand

[2] Mahidol Univ, Fac Sci, Dept Microbiol, Bangkok 10400, Thailand

[3] Univ Oxford, Oxford, England

[4] Charles Darwin Univ, Menzies Sch Hlth Res, Trop & Emerging Infect Dis Div, Darwin, NT, Australia

[5] Flinders Univ S Australia, No Terr Clin Sch, Darwin, NT, Australia

[6] Khon Kaen Univ, Fac Med, Melioidosis Res Ctr, Dept Biochem & Microbiol, Khon Kaen 40002, Thailand

[7] Khon Kaen Univ, Fac Dent, Dept Oral Diagnosis, Khon Kaen 40002, Thailand

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2006年 / 74卷 / 03期

基金：

英国惠康基金;

关键词：

D O I：

10.4269/ajtmh.2006.74.348

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Heterogeneous patterns were obtained for lipopolysaccharide (LPS) from 1,327 Burkholderia pseudomallei isolates by sodium dodecyl sulfate-polyacryl amide gel electrophoresis, silver staining, and immunoblot analysis. Two LPS serotypes (A and B) possessing different ladder profiles and a rough LPS without ladder appearances were identified. All three LPS types were antigenically distinct by immunoblotting. The predominant type A (97%) produced the lowest amount of biofilm. The two less common types (smooth type B and rough type) were found more in clinical than environmental isolates and more in Australian isolates than Thai isolates. These isolates were more often associated with relapse than with primary infection.

引用

页码：348 / 352

页数：5

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[1] Developing a new model for non-insulin dependent diabetes mellitus (NIDDM) by using the Philippine wild mouse, Mus musculus castaneus [J].