γ-Tubulin complexes:: size does matter

被引：46

作者：

Jeng, R ^{[1
]}

Stearns, T ^{[1
]}

机构：

[1] Stanford Univ, Dept Biol Sci, Stanford, CA 94305 USA

来源：

TRENDS IN CELL BIOLOGY | 1999年 / 9卷 / 09期

关键词：

D O I：

10.1016/S0962-8924(99)01621-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

gamma-Tubulin is a conserved component of all microtule-organizing centres and is required for these organelles to nucleate microtubule polymerization. However, the mechanism of nucleation is not known. In addition to its localization to organizing centres, a large pool of gamma-tubulin exists in the cytoplasm in a complex with other proteins. The size of the gamma-tubulin complex and number of associated proteins vary among organisms, and the functional significance of these differences is unknown. Recently, the nature of these gamma-tubulin complexes has been explored in different organisms, and this had led us closer to a molecular understanding of microtubule nucleation.

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页码：339 / 342

页数：4

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