Natural and pharmacological regulation of telomerase

被引：329

作者：

Mergny, JL

Riou, JF

Mailliet, P

Teulade-Fichou, MP

Gilson, E

机构：

[1] Museum Natl Hist Nat, Biophys Lab, CNRS,UMR 8646, INSERM,U201, F-75005 Paris, France

[2] Univ Reims, UFR Pharm, Unite MeDIAN, CNRS,FRE 2141, F-51096 Reims, France

[3] Aventis Pharma SA, Ctr Rech Vitry Alfortville, F-94805 Vitry Sur Seine, France

[4] Coll France, Lab Chim Interact Mol, CNRS, UPR 285, F-75005 Paris, France

[5] Ecole Normale Super Lyon, Lab Biol Mol & Cellulaire, CNRS, UMR 5665, F-69364 Lyon, France

来源：

NUCLEIC ACIDS RESEARCH | 2002年 / 30卷 / 04期

关键词：

D O I：

10.1093/nar/30.4.839

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The extremities of eukaryotic chromosomes are called telomeres. They have a structure unlike the bulk of the chromosome, which allows the cell DNA repair machinery to distinguish them from 'broken' DNA ends. But these specialised structures present a problem when it comes to replicating the DNA. Indeed, telomeric DNA progressively erodes with each round of cell division in cells that do not express telomerase, a specialised reverse transcriptase necessary to fully duplicate the telomeric DNA. Telomerase is expressed in tumour cells but not in most somatic cells and thus telomeres and telomerase may be proposed as attractive targets for the discovery of new anticancer agents.

引用

页码：839 / 865

页数：27

共 395 条

[1] Use of transcriptional regulatory sequences of telomerase (hTER and hTERT) for selective killing of cancer cells [J].