Resistance training enhances insulin-mediated glucose disposal with minimal effect on the tumor necrosis factor-alpha system in older hypertensives

被引:21
作者
Reynolds, TH
Supiano, MA
Dengel, DR
机构
[1] Ithaca Coll, Hlth Sci Ctr, Dept Exercise & Sport Sci, Ithaca, NY 14850 USA
[2] Univ Michigan, Dept Internal Med, Div Geriatr Med, Ann Arbor, MI 48109 USA
[3] Ann Arbor Vet Affairs Healthcare Syst, GRECC, Ann Arbor, MI USA
[4] Univ Minnesota, Sch Kinesiol, Minneapolis, MN 55455 USA
[5] Minneapolis Vet Affairs Med Ctr, Minneapolis, MN USA
来源
METABOLISM-CLINICAL AND EXPERIMENTAL | 2004年 / 53卷 / 03期
关键词
D O I
10.1016/j.metabol.2003.09.017
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The purpose of the present study was to determine if the improvement in insulin sensitivity after resistance training (RT) is associated with a decline in plasma levels of tumor necrosis factor-alpha (TNF-alpha), soluble TNF-alpha receptor 1 (sTNF R1), and soluble TNF receptor 2 (sTNF R2). Eleven older hypertensives (5 men/6 women, 67 +/- 2 years) participated in a 4-month RT program. Following RT there was a significant increase in upper body (P = .029) and lower body strength (P = .001), assessed by the bench press 1-repetition maximum (1RM) and leg press 1RM, respectively. The RT program produced a significant increase in lean body mass (LBM) (P = .029), a trend for a decline in percent body fat (P = .083), and no change in total body mass (P = .958). Insulin-mediated glucose disposal, assessed by the hyperinsulinemic euglycemic clamp procedure, significantly increased following RT (P = .026). Despite the increase in insulin action, plasma levels of TNF-alpha, sTNF R1, and sTNF R2 were not significantly altered by RT (TNF-alpha: P = .118, sTNF R1: P = .184, sTNF R2: P = .168). In conclusion, a 4-month RT program significantly increased insulin-mediated glucose disposal and LBM without a significant reduction in plasma levels of TNF-alpha, sTNF R1, and sTNF R2 in older hypertensive subjects. (C) 2004 Elsevier Inc. All rights reserved.
引用
收藏
页码:397 / 402
页数:6
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