Serotonin receptor 2A blocker (risperidone) has no effect on human polyomavirus JC infection of primary human fetal glial cells

被引：29

作者：

Chapagain, Moti L.

Sumibcay, Laarni

Gurjav, Ulziijargal ^{[2
]}

Kaufusi, Pakieli H.

Kast, Richard E. ^{[3
]}

Nerurkar, Vivek R. ^{[1
,2
]}

机构：

[1] Univ Hawaii Manoa, Dept Trop Med Med Microbiol & Pharmacol, Asia Pacific Inst Trop Med & Infect Dis, John A Burns Sch Med,Retrovirol Res Lab, Honolulu, HI 96813 USA

[2] Univ Hawaii Manoa, Coll Trop Agr & Human Resources, Mol Biosci & Bioengn Grad Program, Honolulu, HI 96813 USA

[3] Univ Vermont, Dept Psychiat, Burlington, VT USA

来源：

JOURNAL OF NEUROVIROLOGY | 2008年 / 14卷 / 05期

基金：

美国国家卫生研究院;

关键词：

JCV; human polyomavirus; PML; serotonin receptor; risperidone; mirtazapine;

D O I：

10.1080/13550280802235916

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A recent report demonstrated that JC virus (JCV) employs serotonin receptor 2A (5HT2AR) to infect the glial cells. To assess the ability of a potent 5HT2AR blocker, risperidone, to inhibit JCV infection, the authors treated primary human fetal glial (PHFG) cells in vitro with risperidone for 24 h and inoculated with JCV(Mad1). There was no significant difference in JCV genome copies or mRNA transcripts and protein expression in treatment-naive and risperidone-treated PHFG cells. These data indicate that risperidone does not inhibit JCV(Mad1) attachment, internalisation, and replication in PHFG cells, and 5HT2AR blockers may not be effective in treating progressive multifocal leukoencephalopathy (PML).

引用

页码：448 / 454

页数：7

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