A convenient synthesis of 5-hydroxy-2'-deoxycytidine phosphoramidite and its incorporation into oligonucleotides

被引：25

作者：

Romieu, A ^{[1
]}

Gasparutto, D ^{[1
]}

Molko, D ^{[1
]}

Cadet, J ^{[1
]}

机构：

[1] CEA,LAB LES ACIDES NUCL,SCIB,DEPT RECH FONDAMENTALE MAT CONDENSEE,F-38054 GRENOBLE 09,FRANCE

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 43期

关键词：

D O I：

10.1016/S0040-4039(97)10024-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Oligonucleotides containing 5-hydroxy-2'-deoxycytidine (2) have been synthesized using the phosphoramidite chemistry. The presence and the integrity of the modified nucleoside in the synthetic oligomers were confirmed by electrospray mass spectrometry and chromatoghraphic analysis of enzymatic digestion coupled with UV detection. (C) 1997 Elsevier Science Ltd.

引用

页码：7531 / 7534

页数：4

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