Effect of granulocyte macrophage-colony stimulating factor (GM-CSF) on 5-FU-induced ulcerative mucositis in hamster buccal pouches

被引：25

作者：

Cho, SA

Park, JH ^{[1
]}

Seok, SH

Juhn, JH

Kim, SJ

Ji, HJ

Choo, YS

Park, JH ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Vet Med, Dept Lab Anim Med, San 56-1,Sillim Dong, Seoul 151742, South Korea

[2] LG Life Sci Ltd, Div Pharmaceut, Prod Dev, Seoul 151742, South Korea

来源：

EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY | 2006年 / 57卷 / 04期

关键词：

mucositis; GM-CSF; 5-FU; hamster buccal pouch; immunohistochemistry;

D O I：

10.1016/j.etp.2005.09.006

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

granulocyte macrophage-colony stimulating factor (GM-CSF) against ulcerative mucositis in hamster buccal Pouch. GM-CSF was topically administered to the buccal pouches of hamsters with two different doses of 5 and 20 mu g/ml. The treatment of GM-CSF led to rapid healing effects in gross and histopathological findings. It decreased expression of pro-inflammatory cytokine mRNA levels in the mucosal tissue of buccal pouches. Also GM-CSF-treated animals showed high numbers of Ki-67 positive cells in basal cell layer. These results Suggest that GM-CSF provided excellent healing effects to ulcerative mucositis in the buccal pouch of hamster. (C) 2005 Elsevier GmbH. All rights reserved.

引用

页码：321 / 328

页数：8

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