Biofuel Cell Operating in Vivo in Rat

被引：115

作者：

Castorena-Gonzalez, Jorge A. ^{[1
,3
,5
]}

Foote, Christopher ^{[3
,5
]}

MacVittie, Kevin ^{[4
]}

Halamek, Jan ^{[4
]}

Halamkova, Lenka ^{[4
]}

Martinez-Lemus, Luis A. ^{[1
,2
,3
,5
]}

Katz, Evgeny ^{[4
]}

机构：

[1] Univ Missouri, Dept Biol Engn, Columbia, MO 65211 USA

[2] Univ Missouri, Dept Med Pharmacol & Physiol, Columbia, MO 65211 USA

[3] Univ Missouri, Dalton Cardiovasc Res Ctr, Columbia, MO 65211 USA

[4] Clarkson Univ, Dept Chem & Biomol Sci, Potsdam, NY 13699 USA

[5] Clarkson Univ, Dept Biol, Potsdam, NY 13699 USA

来源：

ELECTROANALYSIS | 2013年 / 25卷 / 07期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

Implanted biofuel cell; Rat cremaster tissue; Biocatalytic electrodes; PQQ-dependent glucose dehydrogenase; Laccase; Buckypaper; FUEL-CELLS; ENZYME ELECTRODES; CREMASTER MUSCLE; POWER-GENERATION; FABRICATION; BATTERY;

D O I：

10.1002/elan.201300136

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Biocatalytic electrodes made of buckypaper were modified with PQQ-dependent glucose dehydrogenase on the anode and with laccase on the cathode. The enzyme modified electrodes were assembled in a biofuel cell which was first characterized in human serum solution and then the electrodes were placed onto exposed rat cremaster tissue. Glucose and oxygen dissolved in blood were used as the fuel and oxidizer, respectively, for the implanted biofuel cell operation. The steady-state open circuitry voltage of 140 +/- 30mV and short circuitry current of 10 +/- 3 mu A (current density ca. 5 mu Acm(-2) based on the geometrical electrode area of 2cm(2)) were achieved in the in vivo operating biofuel cell. Future applications of implanted biofuel cells for powering of biomedical and sensor devices are discussed.

引用

页码：1579 / 1584

页数：6

共 46 条

[1] Enzymatic biofuel cells for Implantable and microscale devices [J].

Barton, SC ;

Gallaway, J ;

Atanassov, P .

CHEMICAL REVIEWS, 2004, 104 (10) :4867-4886

[2] Mitochondrial biofuel cells: expanding fuel diversity to amino acids [J].

Bhatnagar, Dushyant ;

Xu, Shuai ;

Fischer, Caitlin ;

Arechederra, Robert L. ;

Minteer, Shelley D. .

PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2011, 13 (01) :86-92

[3] A Glucose BioFuel Cell Implanted in Rats [J].

Cinquin, Philippe ;

Gondran, Chantal ;

Giroud, Fabien ;

Mazabrard, Simon ;

Pellissier, Aymeric ;

Boucher, Francois ;

Alcaraz, Jean-Pierre ;

Gorgy, Karine ;

Lenouvel, Francois ;

Mathe, Stephane ;

Porcu, Paolo ;

Cosnier, Serge .

PLOS ONE, 2010, 5 (05)

[4] Enzymes as working or inspirational electrocatalysts for fuel cells and electrolysis [J].

Cracknell, James A. ;

Vincent, Kylie A. ;

Armstrong, Fraser A. .

CHEMICAL REVIEWS, 2008, 108 (07) :2439-2461

[5] Biofuel cells - Recent advances and applications [J].

Davis, Frank ;

Higson, Seamus P. J. .

BIOSENSORS & BIOELECTRONICS, 2007, 22 (07) :1224-1235

[6] Biomechanical energy harvesting: Generating electricity during walking with minimal user effort [J].

Donelan, J. M. ;

Li, Q. ;

Naing, V. ;

Hoffer, J. A. ;

Weber, D. J. ;

Kuo, A. D. .

SCIENCE, 2008, 319 (5864) :807-810

[7] Biofuel Cells for Biomedical Applications: Colonizing the Animal Kingdom [J].

Falk, Magnus ;

Villarrubia, Claudia W. Narvaez ;

Babanova, Sofia ;

Atanassov, Plamen ;

Shleev, Sergey .

CHEMPHYSCHEM, 2013, 14 (10) :2045-2058

[8] Electric Power Generation from Municipal, Food, and Animal Wastewaters Using Microbial Fuel Cells [J].

Fornero, Jeffrey J. ;

Rosenbaum, Miriam ;

Angenent, Larva T. .

ELECTROANALYSIS, 2010, 22 (7-8) :832-843

[9] Implanted Biofuel Cell Operating in a Living Snail [J].

Halamkova, Lenka ;

Halamek, Jan ;

Bocharova, Vera ;

Szczupak, Alon ;

Alfonta, Lital ;

Katz, Evgeny .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2012, 134 (11) :5040-5043

[10] Miniature biofuel cells [J].

Heller, A .

PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2004, 6 (02) :209-216

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