Engineered proteins with Pumilio/fem-3 mRNA binding factor scaffold to manipulate RNA metabolism

被引：52

作者：

Wang, Yang ^{[1
]}

Wang, Zefeng ^{[1
]}

Hall, Traci M. Tanaka ^{[2
]}

机构：

[1] Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Pharmacol, Chapel Hill, NC 27599 USA

[2] NIEHS, Struct Biol Lab, NIH, Res Triangle Pk, NC 27709 USA

来源：

FEBS JOURNAL | 2013年 / 280卷 / 16期

关键词：

protein engineering; protein-RNA interaction; PUF protein; RNA; RNA localization; RNA regulation; RNA-binding protein; splicing; translation; X-ray crystallography; ELEGANS PUF PROTEIN; 3' UNTRANSLATED REGIONS; ALTERNATIVE POLYADENYLATION; SPLICING FACTORS; SPECIFICITY; RECOGNITION; GENE; TARGETS; FAMILY; DOMAIN;

D O I：

10.1111/febs.12367

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pumilio/fem-3 mRNA binding factor proteins are characterized by a sequence-specific RNA-binding domain. RNA recognition module, whose sequence specificity can be reprogrammed, has been fused with functional modules to engineer protein factors with various functions. We summarize the advances made with respect to developing RNA regulatory tools, as well as opportunities for the future.

引用

页码：3755 / 3767

页数：13

共 81 条

[1] Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans [J].

Adelman, Karen ;

Lis, John T. .

NATURE REVIEWS GENETICS, 2012, 13 (10) :720-731

[2] CONTROL OF THE SPERM-OOCYTE SWITCH IN CAENORHABDITIS-ELEGANS HERMAPHRODITES BY THE FEM-3 3' UNTRANSLATED REGION [J].

AHRINGER, J ;

KIMBLE, J .

NATURE, 1991, 349 (6307) :346-348

[3]

Azzam G, 2010, DEVELOPMENT, V137, P2951

[4] A Combinatorial Amino Acid Code for RNA Recognition by Pentatricopeptide Repeat Proteins [J].

Barkan, Alice ;

Rojas, Margarita ;

Fujii, Sota ;

Yap, Aaron ;

Chong, Yee Seng ;

Bond, Charles S. ;

Small, Ian .

PLOS GENETICS, 2012, 8 (08)

[5] PUMILIO IS ESSENTIAL FOR FUNCTION BUT NOT FOR DISTRIBUTION OF THE DROSOPHILA ABDOMINAL DETERMINANT NANOS [J].

BARKER, DD ;

WANG, C ;

MOORE, J ;

DICKINSON, LK ;

LEHMANN, R .

GENES & DEVELOPMENT, 1992, 6 (12A) :2312-2326

[6] The ribonuclease A superfamily: general discussion [J].

Beintema, JJ ;

Kleineidam, RG .

CELLULAR AND MOLECULAR LIFE SCIENCES, 1998, 54 (08) :825-832

[7] Binding specificity and mRNA targets of a C-elegans PUF protein, FBF-1 [J].

Bernstein, D ;

Hook, B ;

Hajarnavis, A ;

Opperman, L ;

Wickens, M .

RNA, 2005, 11 (04) :447-458

[8] A Eukaryotic Translation Initiation Factor 4E-Binding Protein Promotes mRNA Decapping and Is Required for PUF Repression [J].

Blewett, Nathan H. ;

Goldstrohm, Aaron C. .

MOLECULAR AND CELLULAR BIOLOGY, 2012, 32 (20) :4181-4194

[9] RNA-splicing endonuclease structure and function [J].

Calvin, K. ;

Li, H. .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2008, 65 (7-8) :1176-1185

[10] Cooperativity in RNA-Protein Interactions: Global Analysis of RNA Binding Specificity [J].

Campbell, Zachary T. ;

Bhimsaria, Devesh ;

Valley, Cary T. ;

Rodriguez-Martinez, Jose A. ;

Menichelli, Elena ;

Williamson, James R. ;

Ansari, Aseem Z. ;

Wickens, Marvin .

CELL REPORTS, 2012, 1 (05) :570-581

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