A Freshwater Clam (Corbicula fluminea) Extract Improves Cholesterol Metabolism in Rats Fed on a High-Cholesterol Diet

被引：32

作者：

Chijimatsu, Takeshi ^{[1
,2
]}

Tatsuguchi, Iwao ^{[3
]}

Abe, Kazuaki ^{[2
]}

Oda, Hiroaki ^{[3
]}

Mochizuki, Satoshi ^{[4
]}

机构：

[1] Sasaki Food Co Ltd, Oita 8790615, Japan

[2] Shizenshokken Co Ltd, Oita 8790615, Japan

[3] Nagoya Univ, Dept Appl Mol Biosci, Nagoya, Aichi 4648601, Japan

[4] Oita Univ, Fac Educ & Welf Sci, Oita 8701192, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2008年 / 72卷 / 10期

关键词：

freshwater clam extract; cholesterol; bile acids; 7; alpha-hydroxylase;

D O I：

10.1271/bbb.80257

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The effect of a freshwater clam (Corbicula fluminea.) extract (FCE) on cholesterol metabolism in rats fed on a high-cholesterol diet was investigated. When rats were fed various amounts of FCE in addition to the high-cholesterol diet for 2wk, the serum and hepatic cholesterol levels were gradually reduced in a dose-dependent manner, as compared with the control group. The excretion of neutral sterols and bile acids into the feces was increased by feeding FCE. Several phytosterols were detected in the feces of rats fed on the FCE-containing diet. In addition, substantial amounts of phytosterols were found in FCE. Cholesterol 7 alpha-hydroxylase (CYP7A1) mRNA in the liver of the rats fed on the FCE-containing diets was higher than that of rats fed on the high-cholesterol diets without FCE. These results may suggest that enhanced cholesterol degradation and the excretion of neutral sterols and bile acids contributed to the hypocholesterolemic effect of FCE observed in the hypercholesterolemic rats fed on the high-cholesterol diet.

引用

页码：2566 / 2571

页数：6

共 26 条

[1]

Bile acid regulation of gene expression: Roles of nuclear hormone receptors [J].

Chiang, JYL .

ENDOCRINE REVIEWS, 2002, 23 (04) :443-463

[2]

Chijimatsu T, 2008, J JPN SOC FOOD SCI, V55, P63, DOI 10.3136/nskkk.55.63

[3]

EFFECT OF SHELLFISH CONSUMPTION ON CHOLESTEROL ABSORPTION IN NORMOLIPIDEMIC MEN [J].

CHILDS, MT ;

DORSETT, CS ;

FAILOR, A ;

ROIDT, L ;

OMENN, GS .

METABOLISM-CLINICAL AND EXPERIMENTAL, 1987, 36 (01) :31-35

[4]

EFFECTS OF SHELLFISH CONSUMPTION ON LIPOPROTEINS IN NORMOLIPIDEMIC MEN [J].

CHILDS, MT ;

DORSETT, CS ;

KING, IB ;

OSTRANDER, JG ;

YAMANAKA, WK .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 1990, 51 (06) :1020-1027

[5]

CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P159

[6]

Crestani M, 1998, J LIPID RES, V39, P2192

[7]

β-glucan fractions from barley and oats are similarly antiatherogenic in hypercholesterolemic Syrian golden hamsters [J].

Delaney, B ;

Nicolosi, RJ ;

Wilson, TA ;

Carlson, T ;

Frazer, S ;

Zheng, GH ;

Hess, R ;

Ostergren, K ;

Haworth, J ;

Knutson, N .

JOURNAL OF NUTRITION, 2003, 133 (02) :468-475

[8]

FOLCH J, 1957, J BIOL CHEM, V226, P497

[9]

Control of apolipoprotein AI gene expression through synergistic interactions between hepatocyte nuclear factors 3 and 4 [J].

Harnish, DC ;

Malik, S ;

Kilbourne, E ;

Costa, R ;

Karathanasis, SK .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (23) :13621-13628

[10]

IRITANI N, 1979, J NUTR SCI VITAMINOL, V25, P205, DOI 10.3177/jnsv.25.205

← 1 2 3 →