DNA methyl transferase inhibiting halogenated monoterpenes from the Madagascar red marine alga Portieria hornemannii

被引：42

作者：

Andrianasolo, EH

France, D

Cornell-Kennon, S

Gerwick, WH ^{[1
]}

机构：

[1] Oregon State Univ, Coll Pharm, Corvallis, OR 97331 USA

[2] Novartis Inst Biomed Res, Cambridge, MA 02139 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2006年 / 69卷 / 04期

关键词：

D O I：

10.1021/np0503956

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new halogenated monoterpenes, 2, 3, and 4, along with the known compounds halomon ( 1) and two analogues, 5 and 6, were isolated from the Madagascar red marine alga Portieria hornemannii. The structures of all three new compounds were determined by NMR spectroscopy in combination with mass spectrometric data analysis. Two of these monoterpenes (1 and 2) were low micromolar inhibitors of DNA methyl transferase-1.

引用

收藏

页码：576 / 579

页数：4

相关论文

共 22 条

[1] Isolation of halogenated monoterpenes from bioreactor-cultured microplantlets of the macrophytic red algae Ochtodes secundiramea and Portieria hornemannii [J].

Barahona, LF ;

Rorrer, GL .

JOURNAL OF NATURAL PRODUCTS, 2003, 66 (06) :743-751

[2] The role of vanadium bromoperoxidase in the biosynthesis of halogenated marine natural products [J].

Butler, A ;

Carter-Franklin, JN .

NATURAL PRODUCT REPORTS, 2004, 21 (01) :180-188

[3] MARINE HALOPEROXIDASES [J].

BUTLER, A ;

WALKER, JV .

CHEMICAL REVIEWS, 1993, 93 (05) :1937-1944

[4]

CREWS P, 2005, PHARM BIOL S1, V41, P39

[5]

CREWS P, 1991, P 2 ANT DISC DEV S 1

[6] Geometry and halogen regiochemistry determination of vicinal vinyl dihalides by 1H and 13C NMR.: Application to the structure elucidation of prefuroplocamioid, an unusual marine monoterpene [J].

Díaz-Marrero, AR ;

Cueto, M ;

Dorta, E ;

Rovirosa, J ;

San-Martín, A ;

Darias, J .

ORGANIC LETTERS, 2002, 4 (17) :2949-2952

[7] Plasma pharmacokinetics, bioavailability, and tissue distribution in CD2F1 mice of halomon, an antitumor halogenated monoterpene isolated from the red algae Portieria hornemannii [J].

Egorin, MJ ;

Sentz, DL ;

Rosen, DM ;

Ballesteros, MF ;

Kearns, CM ;

Callery, PS ;

Eiseman, JL .

CANCER CHEMOTHERAPY AND PHARMACOLOGY, 1996, 39 (1-2) :51-60

[8] In vitro metabolism by mouse and human liver preparations of halomon, an antitumor halogenated monoterpene [J].

Egorin, MJ ;

Rosen, DM ;

Benjamin, SE ;

Callery, PS ;

Sentz, DL ;

Eiseman, JL .

CANCER CHEMOTHERAPY AND PHARMACOLOGY, 1997, 41 (01) :9-14

[9] A PENTAHALOGENATED MONOTERPENE FROM THE RED ALGA PORTIERIA-HORNEMANNII PRODUCES A NOVEL CYTOTOXICITY PROFILE AGAINST A DIVERSE PANEL OF HUMAN TUMOR-CELL LINES [J].

FULLER, RW ;

CARDELLINA, JH ;

KATO, Y ;

BRINEN, LS ;

CLARDY, J ;

SNADER, KM ;

BOYD, MR .

JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (16) :3007-3011

[10]

Gribble GW, 2003, PROG HET CH, V15, P58