The role of interleukin-1 in allergy-related disorders

被引：76

作者：

Krause, Karoline ^{[1
,2
]}

Metz, Martin ^{[1
,2
]}

Makris, Michael ^{[1
,3
]}

Zuberbier, Torsten ^{[1
,2
]}

Maurer, Marcus ^{[1
,2
]}

机构：

[1] Charite, Dept Dermatol & Allergy, D-10117 Berlin, Germany

[2] Charite, Autoinflammat Reference Ctr Charite, D-10117 Berlin, Germany

[3] Univ Athens, Sch Med, Attikon Univ Hosp, Dept Dermatol & Venerol 2, GR-11527 Athens, Greece

来源：

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY | 2012年 / 12卷 / 05期

关键词：

allergy; inflammasome; interleukin-1; urticaria; T-LYMPHOCYTE RESPONSE; RECEPTOR ANTAGONIST; NLRP3; INFLAMMASOME; DOUBLE-BLIND; AUTOINFLAMMATORY DISEASE; INDUCED ACTIVATION; PERIODIC SYNDROME; MURINE MODEL; IL-1; CANAKINUMAB;

D O I：

10.1097/ACI.0b013e3283574d0c

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Purpose of review Interleukin-1 beta (IL-1 beta) is a potent proinflammatory cytokine, which is involved in many inflammatory conditions including autoinflammatory and allergic disorders. This review provides insights into recent advances of our understanding of the pathogenesis of IL-1 beta-associated allergy-related disorders. Recent findings In autoinflammatory as well as allergic diseases such as contact hypersensitivity, atopic dermatitis and bronchial asthma, dysfunctional inflammasome processing has been demonstrated to account for IL-1 beta-induced inflammation. IL-1-neutralizing drugs have been shown to completely suppress or markedly reduce inflammatory responses in clinical studies and experimental models of urticarial autoinflammatory diseases as well as common allergic disorders. Summary The recent findings support a crucial role for IL-1 beta and inflammasome components in a variety of allergy-related disorders.

引用

页码：477 / 484

页数：8

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