A simple way to synthesize 3D hierarchical HAp porous microspheres with sustained drug release

被引：32

作者：

Yang, Chen ^{[1
]}

Lin, Kaili ^{[1
]}

Chang, Jiang ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

来源：

CERAMICS INTERNATIONAL | 2015年 / 41卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Hydroxyapatite; Porous microspheres; Microwave; Drug-loading and release; FREE HYDROTHERMAL SYNTHESIS; HYDROXYAPATITE MICROSPHERES; MONETITE; TRANSFORMATION; CITRATE;

D O I：

10.1016/j.ceramint.2015.05.064

中图分类号：

TQ174 [陶瓷工业]; TB3 [工程材料学];

学科分类号：

081705 [工业催化]; 082905 [生物质能源与材料];

摘要：

In this paper, a simple and environmentally friendly strategy was developed to synthesize the sphere-like hierarchical structures of HAp which was transformed by using flower-like CaHPO4 as a precursor in NaOH solution. Self-assembly flower-like CaHPO4 can be synthesized in mixed solvents of water and ethanol via microwave-assisted method. The effects of the reaction conditions on the morphology of the product were investigated and a possible formation mechanism was proposed. Furthermore, CaHPO4 microflowers can be transformed to HAp with sphere-like hierarchical structure with the assistance of microwave irradiation. These HAp porous microspheres exhibited high drug-loading capacity and sustained drug release properties due to their novel 3D hierarchical mesoporous structures and high specific surface area. Our study indicated that the fabricated hierarchical HAp porous microspheres might be a potential candidate as drug-delivery biomaterials for hard tissue repair. (C) 2015 Elsevier Ltd and Techna Group S.r.l. All rights reserved.

引用

页码：11153 / 11160

页数：8

共 21 条

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