Evidence for linkage of stature to chromosome 3p26 in a large UK family data set ascertained for type 2 diabetes

被引：44

作者：

Wiltshire, S

Frayling, TM

Hattersley, AT

Hitman, GA

Walker, M

Levy, JC

O'Rahilly, S

Groves, CJ

Menzel, S

Cardon, LR

McCarthy, MI

机构：

[1] Univ London Imperial Coll Sci & Technol, Genet & Gen Res Inst, London W12 0NN, England

[2] Univ London Imperial Coll Sci & Technol, Div Med, London, England

[3] Barts & London Queen Marys Sch Med & Dent, Dept Diabet & Metab Med, London, England

[4] Univ Oxford, Radcliffe Infirm, Wellcome Trust Ctr Human Genet, Oxford OX2 6HE, England

[5] Univ Oxford, Radcliffe Infirm, Oxford Ctr Diabet Endocrinol & Metab, Oxford OX2 6HE, England

[6] Univ Exeter, Sch Postgrad Med & Hlth Sci, Dept Diabet & Vasc Med, Exeter, Devon, England

[7] Newcastle Univ, Sch Med, Dept Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

[8] Univ Cambridge, Addenbrookes Hosp, Dept Med, Cambridge CB2 2QQ, England

[9] Univ Cambridge, Addenbrookes Hosp, Dept Clin Biochem, Cambridge CB2 2QQ, England

来源：

AMERICAN JOURNAL OF HUMAN GENETICS | 2002年 / 70卷 / 02期

关键词：

D O I：

10.1086/338760

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have analyzed data from 573 pedigrees from the United Kingdom for evidence for linkage to loci influencing adult stature. Our data set comprised 1,214 diabetic and 163 nondiabetic siblings for whom height data were available. We used variance-components analysis implemented in GENEHUNTER 2 and a modification of the Haseman-Elston regression method, HE-COM. We found evidence for a locus on 3p26 (LOD score 3.17) influencing height in this adult sample, with less-significant evidence for loci on chromosomes 7, 10, 15, 17, 19, and 20. Our findings extend similar recent studies in Scandinavian and Quebecois populations, adding further evidence that height is indeed under the control of multiple genes.

引用

页码：543 / 546

页数：4

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